Androgen Receptor mRNA Expression in Urothelial Carcinoma of the Bladder: A Retrospective Analysis of Two Independent Cohorts

Journal article


Publication Details

Author(s): Sikic D, Wirtz RM, Wach S, Dyrskjot L, Erben P, Bolenz C, Breyer J, Otte W, Hoadley KA, Lerner SP, Eckstein M, Hartmann A, Keck B
Journal: Translational Oncology
Publication year: 2019
Volume: 12
Journal issue: 4
Pages range: 661-668
ISSN: 1936-5233


Abstract

INTRODUCTION: Gender-specific differences have led to the androgen receptor (AR) being considered a possible factor in the pathophysiology of urothelial carcinoma of the bladder (UCB), but the exact role remains unclear. MATERIALS AND METHODS: The association of AR mRNA expression with clinicopathological features was retrospectively analyzed in two previously described cohorts. The first cohort consisted of 41 patients with all stages of UCB treated at Aarhus University Hospital, Denmark. The second cohort consisted of 323 patients with muscle-invasive bladder cancer (MIBC) accumulated by the Cancer Genome Atlas (TCGA) Research Network. RESULTS: AR mRNA expression is significantly higher in non-muscle-invasive bladder cancer (NMIBC) when compared to MIBC (P = .0004), with no relevant changes within the different stages of MIBC. AR mRNA expression was significantly associated with TCGA molecular subtypes (P < .0001). In the total cohort, there was no association between AR expression and gender (P = .23). When analyzed separately, females showed a significantly worse disease-free (P = .03) and overall survival (P = .02) when expressing AR mRNA above median level, while the same was not observed for men. Multivariable Cox's regression analyses revealed AR mRNA expression to be an independent prognostic marker for disease-free survival in women (P = .007). CONCLUSIONS: AR mRNA expression is significantly higher in NMIBC than in MIBC, while high AR mRNA expression is associated with worse survival in females with MIBC. Further studies need to investigate the gender-specific role of AR in UCB.


FAU Authors / FAU Editors

Eckstein, Markus Dr. med.
Pathologisches Institut
Hartmann, Arndt Prof. Dr. med.
Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie
Keck, Bastian PD Dr.
Medizinische Fakultät


External institutions with authors

Aarhus University Hospital / Aarhus Universitetshospital
Houston Texas Medical Center
Ruprecht-Karls-Universität Heidelberg
STRATIFYER Molecular Pathology GmbH
Universität Regensburg
Universitätsklinikum Ulm
University of North Carolina at Chapel Hill


How to cite

APA:
Sikic, D., Wirtz, R.M., Wach, S., Dyrskjot, L., Erben, P., Bolenz, C.,... Keck, B. (2019). Androgen Receptor mRNA Expression in Urothelial Carcinoma of the Bladder: A Retrospective Analysis of Two Independent Cohorts. Translational Oncology, 12(4), 661-668. https://dx.doi.org/10.1016/j.tranon.2019.01.005

MLA:
Sikic, Danijel, et al. "Androgen Receptor mRNA Expression in Urothelial Carcinoma of the Bladder: A Retrospective Analysis of Two Independent Cohorts." Translational Oncology 12.4 (2019): 661-668.

BibTeX: 

Last updated on 2019-26-03 at 10:08