Growth in disorders and normal variants of puberty

Binder G, Bettendorf M, Dörr HG, Hauffa BP, Reinehr T, Richter-Unruh A, Rohrer TR, Woelfle J (2019)

Publication Type: Journal article, Review article

Publication year: 2019

Journal

Monatsschrift Kinderheilkunde Springer Verlag (Germany)

Book Volume: 167

Pages Range: 220-225

Journal Issue: 3

DOI: 10.1007/s00112-017-0398-6

Abstract

BackgroundDisorders of puberty may affect growth.ObjectiveHow do precocious puberty, constitutional delay of growth and puberty (CDGP) and hypogonadism impact parameters of growth, such as growth velocity, bone maturation and adult height and when is treatment required?Material and methodsThis article is based on the results of a working party meeting of pediatric endocrinologists. Each author carried out areview of the current literature about growth in the context of disorders of pubertal development and the respective treatment.ResultsIf untreated precocious puberty almost always results in short stature in adulthood. Affected children can achieve an individual adult target height if treatment with gonadotropin-releasing hormone (GnRH) analogues is started early. The CDGP is aslow variant of childhood growth rate with normal unaffected adult height and treatment is not necessary. Overweight can be associated with an acceleration of growth and pubertal maturity but adult height is also unaffected. Children with hypogonadism usually reach normal adult height after pharmaceutical induction of puberty. Complex hypothalamic and hypopituitary disorders (hypogonadism plus deficiency of growth hormones), e.g. that can occur after cancer treatment in childhood, need early diagnosis and individualized therapy to preserve the growth potential of the patient.ConclusionEarly diagnosis and adequate therapy of disorders of puberty are the cornerstones for an optimal growth outcome of affected children.

Authors with CRIS profile

Helmuth-Günther Dörr Medizinische Fakultät

Involved external institutions

Universitätsklinikum Tübingen DE Germany (DE) Universitätsklinikum Heidelberg DE Germany (DE) Universität Duisburg-Essen (UDE) DE Germany (DE) Universität Witten/Herdecke DE Germany (DE) Universitätsklinikum Münster DE Germany (DE) Universitätsklinikum des Saarlandes (UKS) DE Germany (DE) Universitätsklinikum Bonn DE Germany (DE)

How to cite

APA:

Binder, G., Bettendorf, M., Dörr, H.-G., Hauffa, B.P., Reinehr, T., Richter-Unruh, A.,... Woelfle, J. (2019). Growth in disorders and normal variants of puberty. Monatsschrift Kinderheilkunde, 167(3), 220-225. https://dx.doi.org/10.1007/s00112-017-0398-6

MLA:

Binder, G., et al. "Growth in disorders and normal variants of puberty." Monatsschrift Kinderheilkunde 167.3 (2019): 220-225.

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