Cytosolic 5 '-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites

Patzak MS, Kari V, Patil S, Hamdan FH, Goetze RG, Brunner M, Gaedcke J, Kitz J, Jodrell D, Richards FM, Pilarsky C, Grützmann R, Rummele P, Knosel T, Hessmann E, Ellenrieder V, Johnsen SA, Neesse A (2019)

Publication Type: Journal article

Publication year: 2019

Journal

EBioMedicine Elsevier

Book Volume: 40

Pages Range: 394-405

DOI: 10.1016/j.ebiom.2019.01.037

Abstract

Background: Cytosolic 5'-nucleotidase 1A (NT5C1A) dephosphorylates non-cyclic nucleoside monophosphates to produce nucleosides and inorganic phosphates. Here, we investigate NT5C1A expression in pancreatic ductal adenocarcinoma (PDAC) and its impact on gemcitabine metabolism and therapeutic efficacy.

Authors with CRIS profile

Christian Pilarsky Professur für Chirurgische Forschung Robert Grützmann Department of Surgery

Involved external institutions

Universitätsklinikum Göttingen DE Germany (DE) Ludwig-Maximilians-Universität (LMU) DE Germany (DE) University of Cambridge GB United Kingdom (GB)

How to cite

APA:

Patzak, M.S., Kari, V., Patil, S., Hamdan, F.H., Goetze, R.G., Brunner, M.,... Neesse, A. (2019). Cytosolic 5 '-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites. EBioMedicine, 40, 394-405. https://doi.org/10.1016/j.ebiom.2019.01.037

MLA:

Patzak, Melanie S., et al. "Cytosolic 5 '-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites." EBioMedicine 40 (2019): 394-405.

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