Bioprinted 3D calcium phosphate scaffolds with gentamicin releasing capability

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Meissner R, Bertol L, Ur Rehman MA, Loureiro Dos Santos LA, Boccaccini AR
Zeitschrift: Ceramics International
Jahr der Veröffentlichung: 2019
Band: 45
Heftnummer: 6
Seitenbereich: 7090-7094
ISSN: 0272-8842


Abstract

We investigated the suitability of 3D printed calcium phosphate scaffolds as drug carriers. The 3D powder printing process utilized a-tricalcium phosphate (alpha-TCP) as a solid phase and deionized water with 2.5% disodium hydrogen phosphate as a setting accelerator. The antibiotic gentamicin sulfate was incorporated by mixing it into alpha-TCP powder before printing. Two different concentrations of gentamicin (3 wt%, 7 wt%) were used to study the correlation between drug release kinetics and gentamicin content in the scaffolds. The scaffolds were hardened at 100% humidity. The synthesized scaffolds were characterized in terms of morphology, composition, mechanical strength, in vitro bioactivity and drug release kinetics. X-ray diffraction (XRD) analysis revealed that the alpha-TCP converted into calcium deficient hydroxyapatite (CDHA) during the printing process. Scanning electron microscopy (SEM) showed the typical needle-like structure of CDHA. Gentamicin release was investigated for a period of two weeks with an initial burst release. The produced scaffolds formed calcium enriched apatite crystals on their surface after three days of incubation in simulated body fluid.


FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Boccaccini, Aldo R. Prof. Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Ur Rehman, Muhammad Atiq
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)


Einrichtungen weiterer Autorinnen und Autoren

Universidade Federal do Rio Grande do Sul (UFRGS)


Zitierweisen

APA:
Meissner, R., Bertol, L., Ur Rehman, M.A., Loureiro Dos Santos, L.A., & Boccaccini, A.R. (2019). Bioprinted 3D calcium phosphate scaffolds with gentamicin releasing capability. Ceramics International, 45(6), 7090-7094. https://dx.doi.org/10.1016/j.ceramint.2018.12.212

MLA:
Meissner, Ruth, et al. "Bioprinted 3D calcium phosphate scaffolds with gentamicin releasing capability." Ceramics International 45.6 (2019): 7090-7094.

BibTeX: 

Zuletzt aktualisiert 2019-26-03 um 10:23