Bioprinted 3D calcium phosphate scaffolds with gentamicin releasing capability

Journal article


Publication Details

Author(s): Meissner R, Bertol L, Ur Rehman MA, Loureiro Dos Santos LA, Boccaccini AR
Journal: Ceramics International
Publication year: 2019
Volume: 45
Journal issue: 6
Pages range: 7090-7094
ISSN: 0272-8842


Abstract

We investigated the suitability of 3D printed calcium phosphate scaffolds as drug carriers. The 3D powder printing process utilized a-tricalcium phosphate (alpha-TCP) as a solid phase and deionized water with 2.5% disodium hydrogen phosphate as a setting accelerator. The antibiotic gentamicin sulfate was incorporated by mixing it into alpha-TCP powder before printing. Two different concentrations of gentamicin (3 wt%, 7 wt%) were used to study the correlation between drug release kinetics and gentamicin content in the scaffolds. The scaffolds were hardened at 100% humidity. The synthesized scaffolds were characterized in terms of morphology, composition, mechanical strength, in vitro bioactivity and drug release kinetics. X-ray diffraction (XRD) analysis revealed that the alpha-TCP converted into calcium deficient hydroxyapatite (CDHA) during the printing process. Scanning electron microscopy (SEM) showed the typical needle-like structure of CDHA. Gentamicin release was investigated for a period of two weeks with an initial burst release. The produced scaffolds formed calcium enriched apatite crystals on their surface after three days of incubation in simulated body fluid.


FAU Authors / FAU Editors

Boccaccini, Aldo R. Prof. Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Ur Rehman, Muhammad Atiq
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)


External institutions with authors

Universidade Federal do Rio Grande do Sul (UFRGS)


How to cite

APA:
Meissner, R., Bertol, L., Ur Rehman, M.A., Loureiro Dos Santos, L.A., & Boccaccini, A.R. (2019). Bioprinted 3D calcium phosphate scaffolds with gentamicin releasing capability. Ceramics International, 45(6), 7090-7094. https://dx.doi.org/10.1016/j.ceramint.2018.12.212

MLA:
Meissner, Ruth, et al. "Bioprinted 3D calcium phosphate scaffolds with gentamicin releasing capability." Ceramics International 45.6 (2019): 7090-7094.

BibTeX: 

Last updated on 2019-26-03 at 10:23