Bioprinted 3D calcium phosphate scaffolds with gentamicin releasing capability

Meissner R, Bertol L, Ur Rehman MA, Loureiro Dos Santos LA, Boccaccini AR (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Ceramics International Elsevier

Book Volume: 45

Pages Range: 7090-7094

Journal Issue: 6

DOI: 10.1016/j.ceramint.2018.12.212

Abstract

We investigated the suitability of 3D printed calcium phosphate scaffolds as drug carriers. The 3D powder printing process utilized a-tricalcium phosphate (alpha-TCP) as a solid phase and deionized water with 2.5% disodium hydrogen phosphate as a setting accelerator. The antibiotic gentamicin sulfate was incorporated by mixing it into alpha-TCP powder before printing. Two different concentrations of gentamicin (3 wt%, 7 wt%) were used to study the correlation between drug release kinetics and gentamicin content in the scaffolds. The scaffolds were hardened at 100% humidity. The synthesized scaffolds were characterized in terms of morphology, composition, mechanical strength, in vitro bioactivity and drug release kinetics. X-ray diffraction (XRD) analysis revealed that the alpha-TCP converted into calcium deficient hydroxyapatite (CDHA) during the printing process. Scanning electron microscopy (SEM) showed the typical needle-like structure of CDHA. Gentamicin release was investigated for a period of two weeks with an initial burst release. The produced scaffolds formed calcium enriched apatite crystals on their surface after three days of incubation in simulated body fluid.

Authors with CRIS profile

Muhammad Atiq Ur Rehman Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Universidade Federal do Rio Grande do Sul (UFRGS) BR Brazil (BR)

How to cite

APA:

Meissner, R., Bertol, L., Ur Rehman, M.A., Loureiro Dos Santos, L.A., & Boccaccini, A.R. (2019). Bioprinted 3D calcium phosphate scaffolds with gentamicin releasing capability. Ceramics International, 45(6), 7090-7094. https://dx.doi.org/10.1016/j.ceramint.2018.12.212

MLA:

Meissner, Ruth, et al. "Bioprinted 3D calcium phosphate scaffolds with gentamicin releasing capability." Ceramics International 45.6 (2019): 7090-7094.

BibTeX: Download