Potential life-years gained over a 5-year period by correcting DOPPS-identified modifiable practices in haemodialysis: results from the European MONITOR-CKD5 study

Combe C, Mann J, Goldsmith D, Dellanna F, Zaoui P, London G, Denhaerynck K, Krendyukov A, Abraham I, Macdonald K (2019)

Publication Type: Journal article

Publication year: 2019

Journal

BMC Nephrology BMC

Book Volume: 20

DOI: 10.1186/s12882-019-1251-z

Abstract

BackgroundDOPPS reported that thousands of life-years could be gained in the US and Europe over 5years by correcting six modifiable haemodialysis practices. We estimated potential life-years gained across 10 European countries using MONITOR-CKD5 study data.MethodsThe DOPPS-based target ranges were used, except for haemoglobin due to label changes, as well as DOPPS-derived relative mortality risks. Percentages of MONITOR-CKD5 patients outside targets were calculated. Consistent with the DOPPS-based analyses, we extrapolated life-years gained for the MONITOR-CKD5 population over 5years if all patients were within targets.ResultsBringing the 10 MONITOR-CKD5 countries' dialysis populations into compliance on the six practices results in a 5-year gain of 97,428 patient-years. In descending order, survival impact was the highest for albumin levels, followed by phosphate levels, vascular access, haemoglobin, dialysis adequacy, and interdialytic weight gain.ConclusionsOptimal management of the six modifiable haemodialysis practices may achieve 6.2% increase in 5-year survival.Trial RegistrationNCT01121237. Clinicaltrials.gov registration May 12, 2010 (retrospectively registered).

Involved external institutions

Matrix 45 Evidence-Based Healthcare US United States (USA) (US) Hexal AG DE Germany (DE) Centre Hospitalier Manhès FR France (FR) DaVita Clinical Research US United States (USA) (US) University of Grenoble Alpes (UGA) / Université de Grenoble FR France (FR) Guy's and St Thomas' (NHS Foundation Trust) GB United Kingdom (GB) Centre Hospitalier Universitaire de Bordeaux / CHU Bordeaux FR France (FR)

How to cite

APA:

Combe, C., Mann, J., Goldsmith, D., Dellanna, F., Zaoui, P., London, G.,... Macdonald, K. (2019). Potential life-years gained over a 5-year period by correcting DOPPS-identified modifiable practices in haemodialysis: results from the European MONITOR-CKD5 study. BMC Nephrology, 20. https://dx.doi.org/10.1186/s12882-019-1251-z

MLA:

Combe, Christian, et al. "Potential life-years gained over a 5-year period by correcting DOPPS-identified modifiable practices in haemodialysis: results from the European MONITOR-CKD5 study." BMC Nephrology 20 (2019).

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