Electrophoretic Deposition of Bioadaptive Drug Delivery Coatings on Magnesium Alloy for Bone Repair

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autor(en): Qi H, Heise S, Zhou J, Schuhladen K, Yang Y, Cui N, Dong R, Virtanen S, Chen Q, Boccaccini AR, Lu T
Zeitschrift: ACS Applied Materials and Interfaces
Jahr der Veröffentlichung: 2019
Band: 11
Heftnummer: 8
Seitenbereich: 8625-8634
ISSN: 1944-8244


Abstract

Biodegradable polymer coatings on magnesium alloys are attractive, as they can provide corrosion resistance as well as additional functions for biomedical applications, e.g., drug delivery. A gelatin nanospheres/chitosan (GNs/CTS) composite coating on WE43 substrate was fabricated by electrophoretic deposition with simvastatin (SIM) loaded into the GNs. Apart from a sustained drug release over 28 days, an anticorrosion behavior of the coated WE43 substrates was confirmed by electrochemical tests. Both the degradation and corrosion rates of the coated substrate were significantly minimized in contrast to bare WE43. The cytocompatibility of the coated samples was analyzed both quantitatively and qualitatively. Additionally, the osteogenic differentiation of MC3T3El cells on SIM-containing coatings was assessed by measuring the expression of osteogenic genes and related proteins, alkaline phosphatase (ALP) activity, and extracellular matrix mineralization, showing that the SIM-loaded composite coating could upregulate the expression of osteogenic genes and related proteins, promote ALP activity, and enhance extracellular matrix mineralization. In summary, the SIM-loaded GNs/CTS composite coatings were able to enhance the corrosion resistance of the WE43 substrate and promote osteogenic activity, thus demonstrating a promising coating system for modifying the surface of magnesium alloys targeted for orthopedic applications.


FAU-Autoren / FAU-Herausgeber

Boccaccini, Aldo R. Prof. Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Heise, Svenja
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Schuhladen, Katharina
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Virtanen, Sannakaisa Prof. Dr.
Professur für Werkstoffwissenschaften (Korrosion und Oberflächentechnik)
Zhou, Juncen
Lehrstuhl für Werkstoffwissenschaften (Korrosion und Oberflächentechnik)


Autor(en) der externen Einrichtung(en)
Harbin Engineering University (HEU) / 哈尔滨工程大学
Northwestern Polytechnical University / 西北工业大学 (NPU/NWPU)


Zitierweisen

APA:
Qi, H., Heise, S., Zhou, J., Schuhladen, K., Yang, Y., Cui, N.,... Lu, T. (2019). Electrophoretic Deposition of Bioadaptive Drug Delivery Coatings on Magnesium Alloy for Bone Repair. ACS Applied Materials and Interfaces, 11(8), 8625-8634. https://dx.doi.org/10.1021/acsami.9b01227

MLA:
Qi, Hongfei, et al. "Electrophoretic Deposition of Bioadaptive Drug Delivery Coatings on Magnesium Alloy for Bone Repair." ACS Applied Materials and Interfaces 11.8 (2019): 8625-8634.

BibTeX: 

Zuletzt aktualisiert 2019-20-03 um 13:08