Influence of Low Protein Diet-Induced Fetal Growth Restriction on the Neuroplacental Corticosterone Axis in the Rat

Journal article


Publication Details

Author(s): Schmidt M, Rauh M, Schmid MC, Hübner H, Rübner M, Wachtveitl R, Cordasic N, Rascher W, Menendez-Castro C, Hartner A, Fahlbusch FB
Journal: Frontiers in Endocrinology
Publication year: 2019
Volume: 10
ISSN: 1664-2392


Abstract

Objectives: Placental steroid metabolism is linked to the fetal hypothalamus-pituitary-adrenal axis. Intrauterine growth restriction (IUGR) might alter this cross-talk and lead to maternal stress, in turn contributing to the pathogenesis of anxiety-related disorders of the offspring, which might be mediated by fetal overexposure to, or a reduced local enzymatic protection against maternal glucocorticoids. So far, direct evidence of altered levels of circulating/local glucocorticoids is scarce. Liquid chromatography tandem-mass spectrometry (LC-MS/MS) allows quantitative endocrine assessment of blood and tissue. Using a rat model of maternal protein restriction (low protein [LP] vs. normal protein [NP]) to induce IUGR, we analyzed fetal and maternal steroid levels via LC-MS/MS along with the local expression of 11beta-hydroxysteroid- dehydrogenase (Hsd11b).


FAU Authors / FAU Editors

Hartner, Andrea Prof. Dr.
Medizinische Fakultät
Hübner, Hanna Dr. rer. nat.
Frauenklinik
Rascher, Wolfgang Prof. Dr. med.
Kinder- und Jugendklinik
Rauh, Manfred Prof. Dr.
Kinder- und Jugendklinik
Rübner, Matthias Dr. rer. nat.
Frauenklinik


External institutions
Rheinische Friedrich-Wilhelms-Universität Bonn


How to cite

APA:
Schmidt, M., Rauh, M., Schmid, M.C., Hübner, H., Rübner, M., Wachtveitl, R.,... Fahlbusch, F.B. (2019). Influence of Low Protein Diet-Induced Fetal Growth Restriction on the Neuroplacental Corticosterone Axis in the Rat. Frontiers in Endocrinology, 10. https://dx.doi.org/10.3389/fendo.2019.00124

MLA:
Schmidt, Marius, et al. "Influence of Low Protein Diet-Induced Fetal Growth Restriction on the Neuroplacental Corticosterone Axis in the Rat." Frontiers in Endocrinology 10 (2019).

BibTeX: 

Last updated on 2019-26-03 at 10:08