Influence of Low Protein Diet-Induced Fetal Growth Restriction on the Neuroplacental Corticosterone Axis in the Rat

Schmidt M, Rauh M, Schmid MC, Hübner H, Rübner M, Wachtveitl R, Cordasic N, Rascher W, Menendez-Castro C, Hartner A, Fahlbusch FB (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Frontiers in Endocrinology Frontiers Media

Book Volume: 10

DOI: 10.3389/fendo.2019.00124

Abstract

Objectives: Placental steroid metabolism is linked to the fetal hypothalamus-pituitary-adrenal axis. Intrauterine growth restriction (IUGR) might alter this cross-talk and lead to maternal stress, in turn contributing to the pathogenesis of anxiety-related disorders of the offspring, which might be mediated by fetal overexposure to, or a reduced local enzymatic protection against maternal glucocorticoids. So far, direct evidence of altered levels of circulating/local glucocorticoids is scarce. Liquid chromatography tandem-mass spectrometry (LC-MS/MS) allows quantitative endocrine assessment of blood and tissue. Using a rat model of maternal protein restriction (low protein [LP] vs. normal protein [NP]) to induce IUGR, we analyzed fetal and maternal steroid levels via LC-MS/MS along with the local expression of 11beta-hydroxysteroid- dehydrogenase (Hsd11b).

Authors with CRIS profile

Manfred Rauh Department of Paediatrics and Adolescent Medicine Hanna Hübner Department of Obstetrics and Gynaecology Matthias Rübner Department of Obstetrics and Gynaecology Wolfgang Rascher Department of Paediatrics and Adolescent Medicine Andrea Hartner Medizinische Fakultät

Involved external institutions

Rheinische Friedrich-Wilhelms-Universität Bonn DE Germany (DE)

How to cite

APA:

Schmidt, M., Rauh, M., Schmid, M.C., Hübner, H., Rübner, M., Wachtveitl, R.,... Fahlbusch, F.B. (2019). Influence of Low Protein Diet-Induced Fetal Growth Restriction on the Neuroplacental Corticosterone Axis in the Rat. Frontiers in Endocrinology, 10. https://dx.doi.org/10.3389/fendo.2019.00124

MLA:

Schmidt, Marius, et al. "Influence of Low Protein Diet-Induced Fetal Growth Restriction on the Neuroplacental Corticosterone Axis in the Rat." Frontiers in Endocrinology 10 (2019).

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