Repeating of local therapy of distant metastases increases overall survival in patients with synchronous metastasized rectal cancer-a monocentric analysis

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Haderlein M, Lettmaier S, Langheinrich M, Schmid A, Semrau S, Hecht M, Beck M, Schmidt D, Grützmann R, Fietkau R, Denz A
Zeitschrift: International Journal of Colorectal Disease
Jahr der Veröffentlichung: 2018
Band: 33
Heftnummer: 11
Seitenbereich: 1533-1541
ISSN: 0179-1958


Abstract

PURPOSE: The aim was to evaluate the outcome of treatment-naive patients with synchronous metastatic rectal cancer after chemotherapy with FOLFOXIRI followed by local therapeutic procedures of all tumor lesions as complete as possible.
METHODS: We reviewed data of 30 patients with synchronous distant metastatic rectal cancer who underwent chemotherapy with FOLFOXIRI and subsequent local therapy in our institution.
RESULTS: Median follow-up was 28 months (range: 8; 74). Cumulative overall survival (OS) and progression-free survival (PFS) was 93.3, 76.9, 55.6% and 46.2, 29.7, 29.7% after 1, 2, 4 years. Non-response to chemotherapy with FOLFOXIRI was associated with a highly significant decreased OS (p < 0.0001). The consistent use of local ablative procedures led to a statistically significant increase in OS (p < 0.0001), but not in PFS (p = 0.635). Patients with ≤ 4 distant metastases showed a better OS (p = 0.033).
CONCLUSIONS: Response to intensified first-line chemotherapy with FOLFOXIRI, treatment of the primary rectal tumor, and repeated thorough local ablative procedures in patients with synchronous metastasized rectal cancer may lead to long-term survival, even in a subset of patients with unresectable disease at initial diagnosis.


FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Beck, Michael
Lehrstuhl für Klinische Nuklearmedizin
Fietkau, Rainer Prof. Dr.
Lehrstuhl für Strahlentherapie
Grützmann, Robert Prof. Dr.
Chirurgische Klinik
Haderlein, Marlen Dr. med.
Strahlenklinik
Hecht, Markus PD Dr.
Strahlenklinik
Schmid, Axel PD Dr.
Radiologisches Institut
Schmidt, Daniela PD Dr.
Medizinische Fakultät


Zitierweisen

APA:
Haderlein, M., Lettmaier, S., Langheinrich, M., Schmid, A., Semrau, S., Hecht, M.,... Denz, A. (2018). Repeating of local therapy of distant metastases increases overall survival in patients with synchronous metastasized rectal cancer-a monocentric analysis. International Journal of Colorectal Disease, 33(11), 1533-1541. https://dx.doi.org/10.1007/s00384-018-3113-8

MLA:
Haderlein, Marlen, et al. "Repeating of local therapy of distant metastases increases overall survival in patients with synchronous metastasized rectal cancer-a monocentric analysis." International Journal of Colorectal Disease 33.11 (2018): 1533-1541.

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Zuletzt aktualisiert 2019-20-03 um 16:10