Haderlein M, Lettmaier S, Langheinrich M, Schmid A, Semrau S, Hecht M, Beck M, Schmidt D, Grützmann R, Fietkau R, Denz A (2018)
Publication Type: Journal article
Publication year: 2018
Book Volume: 33
Pages Range: 1533-1541
Journal Issue: 11
DOI: 10.1007/s00384-018-3113-8
PURPOSE: The aim was to evaluate the outcome of treatment-naive patients with synchronous metastatic rectal cancer after chemotherapy with FOLFOXIRI followed by local therapeutic procedures of all tumor lesions as complete as possible. METHODS: We reviewed data of 30 patients with synchronous distant metastatic rectal cancer who underwent chemotherapy with FOLFOXIRI and subsequent local therapy in our institution. RESULTS: Median follow-up was 28 months (range: 8; 74). Cumulative overall survival (OS) and progression-free survival (PFS) was 93.3, 76.9, 55.6% and 46.2, 29.7, 29.7% after 1, 2, 4 years. Non-response to chemotherapy with FOLFOXIRI was associated with a highly significant decreased OS (p < 0.0001). The consistent use of local ablative procedures led to a statistically significant increase in OS (p < 0.0001), but not in PFS (p = 0.635). Patients with ≤ 4 distant metastases showed a better OS (p = 0.033). CONCLUSIONS: Response to intensified first-line chemotherapy with FOLFOXIRI, treatment of the primary rectal tumor, and repeated thorough local ablative procedures in patients with synchronous metastasized rectal cancer may lead to long-term survival, even in a subset of patients with unresectable disease at initial diagnosis.
APA:
Haderlein, M., Lettmaier, S., Langheinrich, M., Schmid, A., Semrau, S., Hecht, M.,... Denz, A. (2018). Repeating of local therapy of distant metastases increases overall survival in patients with synchronous metastasized rectal cancer-a monocentric analysis. International Journal of Colorectal Disease, 33(11), 1533-1541. https://dx.doi.org/10.1007/s00384-018-3113-8
MLA:
Haderlein, Marlen, et al. "Repeating of local therapy of distant metastases increases overall survival in patients with synchronous metastasized rectal cancer-a monocentric analysis." International Journal of Colorectal Disease 33.11 (2018): 1533-1541.
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