Rate of individuals with clearly increased radiosensitivity rise with age both in healthy individuals and in cancer patients
Schuster B, Ellmann A, Mayo T, Auer J, Haas M, Hecht M, Fietkau R, Distel L (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 18
Journal Issue: 1
DOI: 10.1186/s12877-018-0799-y
Abstract
BACKGROUND: The question of an age dependence of individual radiosensitivity has only marginally been studied so far. Therefore, we analyzed blood samples of healthy individuals and cancer patients of different ages to determine individual radiosensitivity. METHODS: Ex vivo irradiated blood samples of 595 individuals were tested. Chromosomes 1, 2 and 4 were stained by 3-color fluorescence in situ hybridization and aberrations were analyzed. Radiosensitivity was determined by the mean breaks per metaphase (B/M). RESULTS: Healthy individuals (mean age 50.7 years) had an average B/M value of 0.42 ± 0.104 and an increase of 0.0014B/M per year. The patients (mean age 60.4 years) had an average B/M value of 0.44 ± 0.150 and radiosensitivity did not change with age. In previous studies we found that from a value of 0.6B/M on an individual is considered to be distinctly radiosensitive. The portion of radiosensitive individuals (B/M > 0.6) increased in both cohorts with age. CONCLUSION: Individual radiosensitivity rises continuously with age, yet with strong interindividual variation. No age related increase of radiosensitivity can be demonstrated in patients due to the strong interindividual variation. However among old cancer patients there is a higher probability to have patients with clearly increased radiosensitivity than at younger age.
Authors with CRIS profile
Barbara Schuster
Department of Radiation Oncology
Anna Ellmann
Lehrstuhl für Strahlentherapie
Theresa Mayo
Department of Radiation Oncology
Judith Auer
Medizinische Fakultät
Markus Hecht
Department of Radiation Oncology
Rainer Fietkau
Lehrstuhl für Strahlentherapie
Luitpold Distel
Department of Radiation Oncology
Involved external institutions
Germany (DE)How to cite
APA:
Schuster, B., Ellmann, A., Mayo, T., Auer, J., Haas, M., Hecht, M.,... Distel, L. (2018). Rate of individuals with clearly increased radiosensitivity rise with age both in healthy individuals and in cancer patients. BMC Geriatrics, 18(1). https://dx.doi.org/10.1186/s12877-018-0799-y
MLA:
Schuster, Barbara, et al. "Rate of individuals with clearly increased radiosensitivity rise with age both in healthy individuals and in cancer patients." BMC Geriatrics 18.1 (2018).
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