Feasibility, safety and diagnostic impact of endomyocardial biopsies for the diagnosis of myocardial disease in children and adolescents
Mueller GC, Michel-Behnke I, Knirsch W, Haas NA, Abdul-Khaliq H, Gitter R, Dittrich S, Daehnert I, Uhlemann F, Schubert S, Tarusinov G, Happel C, Bertram H, Sieverding L, Eicken A, Kozlik-Feldmann R, Weil J (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 14
Pages Range: 1089-1095
Journal Issue: 10
Abstract
AIMS: Endomyocardial biopsies (EMBs) are performed infrequently in children owing to significant past complication rates and controversial discussions about the therapeutic value of results. The objective of this study was to investigate the safety and feasibility of EMBs for suspected myocardial disease in relation to their clinical value. METHODS AND RESULTS: We performed a retrospective multicentre review of the Working Group for Interventional Cardiology of the German Society for Paediatric Cardiology. During three consecutive years, 206 EMBs (84 female/mean age 8.95±6.62 years) were performed and analysed at 15 heart centres. In the majority of cases, biopsies were taken from the right ventricle (RV/89.8%; p<0.001). The overall complication rate was 9.7%, whereas major complications occurred in only 0.97% of cases. Risk factors associated with a higher complication rate were biopsy during the first year of life (20.5%) and from the left ventricle (31.1%) (p<0.05). There was no procedure-related mortality. Treatment was changed in 18.0% of cases based on biopsy results. CONCLUSIONS: Today, endomyocardial biopsies in older children with suspected myocardial disease can be performed safely with a low risk of major complications and mortality, whereas the risk of complications if the biopsy is carried out in the first year of life or taken from the left ventricle remains high.
Authors with CRIS profile
Involved external institutions
Herzzentrum Duisburg
Germany (DE)
Universitätsklinikum Hamburg-Eppendorf (UKE)
Germany (DE)
HELIOS Kliniken
Germany (DE)
Deutsches Herzzentrum München
Germany (DE)
Deutsches Herzzentrum Berlin
Germany (DE)
Ludwig-Maximilians-Universität (LMU)
Germany (DE)
Eberhard Karls Universität Tübingen
Germany (DE)
Medizinische Hochschule Hannover (MHH) / Hannover Medical School
Germany (DE)
Universitäts-Kinderspital Zürich
Switzerland (CH)
Klinikum Stuttgart
Germany (DE)
Medizinische Universität Wien
Austria (AT)
Kepler Universitätsklinikum (KUK)
Austria (AT)
Germany (DE)
Universitätsklinikum Hamburg-Eppendorf (UKE)
Germany (DE)
HELIOS Kliniken
Germany (DE)
Deutsches Herzzentrum München
Germany (DE)
Deutsches Herzzentrum Berlin
Germany (DE)
Ludwig-Maximilians-Universität (LMU)
Germany (DE)
Eberhard Karls Universität Tübingen
Germany (DE)
Medizinische Hochschule Hannover (MHH) / Hannover Medical School
Germany (DE)
Universitäts-Kinderspital Zürich
Switzerland (CH)
Klinikum Stuttgart
Germany (DE)
Medizinische Universität Wien
Austria (AT)
Kepler Universitätsklinikum (KUK)
Austria (AT)
How to cite
APA:
Mueller, G.C., Michel-Behnke, I., Knirsch, W., Haas, N.A., Abdul-Khaliq, H., Gitter, R.,... Weil, J. (2018). Feasibility, safety and diagnostic impact of endomyocardial biopsies for the diagnosis of myocardial disease in children and adolescents. EuroIntervention, 14(10), 1089-1095. https://dx.doi.org/10.4244/EIJ-D-18-00128
MLA:
Mueller, Goetz C., et al. "Feasibility, safety and diagnostic impact of endomyocardial biopsies for the diagnosis of myocardial disease in children and adolescents." EuroIntervention 14.10 (2018): 1089-1095.
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