Individualization of post-mastectomy radiotherapy and regional nodal irradiation based on treatment response after neoadjuvant chemotherapy for breast cancer : A systematic review

Krug D, Baumann R, Budach W, Dunst J, Feyer P, Fietkau R, Haase W, Harms W, Hehr T, Piroth MD, Sedlmayer F, Souchon R, Wenz F, Sauer R (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Strahlentherapie und Onkologie Urban & Vogel

Book Volume: 194

Pages Range: 607-618

Journal Issue: 7

DOI: 10.1007/s00066-018-1270-x

Abstract

PURPOSE: To review the evidence regarding post-mastectomy radiotherapy (PMRT) and regional nodal irradiation (RNI) after neoadjuvant chemotherapy (NACT) for breast cancer, with a special focus on individualization of adjuvant radiotherapy based on treatment response. METHODS: A systematic literature search using the PubMed/Medline database was performed. We included prospective and retrospective reports with a minimum of 10 patients that had been published since 1st January 2000, and provided clinical outcome data analyzed by treatment response and radiotherapy. RESULTS: Out of 763 articles identified via PubMed/Medline and hand search, 68 full text-articles were assessed for eligibility after screening of title and abstract. 13 studies were included in the systematic review, 9 for PMRT and 5 for RNI. All included studies were retrospective reports. CONCLUSIONS: There is a considerable lack of evidence regarding the role of adjuvant radiotherapy and its individualization based on treatment response after NACT. Results of prospective randomized trials such as NSABP B‑51/RTOG 1304 and Alliance A11202 are eagerly awaited.

Authors with CRIS profile

Rainer Fietkau Lehrstuhl für Strahlentherapie

Involved external institutions

Universitätsklinikum Heidelberg DE Germany (DE) Universität Witten/Herdecke DE Germany (DE) Universitätsklinikum Schleswig-Holstein (UKSH) DE Germany (DE) Ruprecht-Karls-Universität Heidelberg DE Germany (DE) Marienhospital Stuttgart DE Germany (DE) Paracelsus Medizinische Privatuniversität AT Austria (AT) Vivantes - Netzwerk für Gesundheit GmbH DE Germany (DE) St. Vincentius-Kliniken / ViDia Kliniken DE Germany (DE) Heinrich-Heine-Universität Düsseldorf DE Germany (DE) St. Claraspital AG CH Switzerland (CH) Universitätsklinikum Tübingen DE Germany (DE)

How to cite

APA:

Krug, D., Baumann, R., Budach, W., Dunst, J., Feyer, P., Fietkau, R.,... Sauer, R. (2018). Individualization of post-mastectomy radiotherapy and regional nodal irradiation based on treatment response after neoadjuvant chemotherapy for breast cancer : A systematic review. Strahlentherapie und Onkologie, 194(7), 607-618. https://dx.doi.org/10.1007/s00066-018-1270-x

MLA:

Krug, David, et al. "Individualization of post-mastectomy radiotherapy and regional nodal irradiation based on treatment response after neoadjuvant chemotherapy for breast cancer : A systematic review." Strahlentherapie und Onkologie 194.7 (2018): 607-618.

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