Interdisciplinary Diagnosis, Therapy and Follow-up of Patients with Endometrial Cancer. Guideline (S3-Level, AWMF Registry Nummer 032/034-OL, April 2018) - Part 1 with Recommendations on the Epidemiology, Screening, Diagnosis and Hereditary Factors of Endometrial Cancer

Emons G, Steiner E, Vordermark D, Uleer C, Bock N, Paradiess K, Ortmann O, Aretz S, Mallmann P, Kurzeder C, Hagen V, Van Oorschot B, Hoecht S, Feyer P, Egerer G, Friedrich M, Cremer W, Prott FJ, Horn LC, Proempeler H, Langrehr J, Leinung S, Beckmann M, Kimmig R, Letsch A, Reinhardt M, Alt-Epping B, Kiesel L, Menke J, Gebhardt M, Steinke-Lange V, Rahner N, Lichtenegger W, Zeimet A, Hanf V, Weis J, Mueller M, Henscher U, Schmutzler RK, Meindl A, Hilpert F, Panke JE, Strnad V, Niehues C, Dauelsberg T, Niehoff P, Mayr D, Grab D, Kreissl M, Witteler R, Schorsch A, Mustea A, Petru E, Huebner J, Rose AD, Wight E, Tholen R, Bauerschmitz GJ, Fleisch M, Juhasz-Boess I, Sigurd L, Runnebaum I, Tempfer C, Nothacker MJ, Bloedt S, Follmann M, Langer T, Raatz H, Wesselmann S, Erdogan S (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Book Volume: 78

Pages Range: 949-971

Journal Issue: 10

DOI: 10.1055/a-0713-1218

Abstract

Summary The first German interdisciplinary S3-guideline on the diagnosis, therapy and follow-up of patients with endometrial cancer was published in April 2018. Funded by German Cancer Aid as part of an Oncology Guidelines Program, the lead coordinators of the guideline were the German Society of Gynecology and Obstetrics (DGGG) and the Gynecological Oncology Working Group (AGO) of the German Cancer Society (DKG). Purpose The use of evidence-based, risk-adapted therapy to treat low-risk women with endometrial cancer avoids unnecessarily radical surgery and non-useful adjuvant radiotherapy and/or chemotherapy. This can significantly reduce therapy-induced morbidity and improve the patient's quality of life as well as avoiding unnecessary costs. For women with endometrial cancer and a high risk of recurrence, the guideline defines the optimal surgical radicality together with the appropriate chemotherapy and/or adjuvant radiotherapy where required. The evidence-based optimal use of different therapeutic modalities should improve survival rates and the quality of life of these patients. The S3-guideline on endometrial cancer is intended as a basis for certified gynecological cancer centers. The aim is that the quality indicators established in this guideline will be incorporated in the certification processes of these centers. Methods The guideline was compiled in accordance with the requirements for S3-level guidelines. This includes, in the first instance, the adaptation of source guidelines selected using the DELBI instrument for appraising guidelines. Other consulted sources include reviews of evidence which were compiled from literature selected during systematic searches of literature databases using the PICO scheme. In addition, an external biostatistics institute was commissioned to carry out a systematic search and assessment of the literature for one area of the guideline. The identified materials were used by the interdisciplinary working groups to develop suggestions for Recommendations and Statements, which were then modified during structured consensus conferences and/or additionally amended online using the DELPHI method with consent being reached online. The guideline report is freely available online. Recommendations Part 1 of this short version of the guideline presents recommendations on epidemiology, screening, diagnosis and hereditary factors, The epidemiology of endometrial cancer and the risk factors for developing endomentrial cancer are presented. The options for screening and the methods used to diagnose endometrial cancer including the pathology of the cancer are outlined. Recommendations are given for the prevention, diagnosis, and therapy of hereditary forms of endometrial cancer.

Authors with CRIS profile

Involved external institutions

Universitätsklinikum Essen Germany (DE) Universität Regensburg Germany (DE) Universitätsklinikum Würzburg Germany (DE) Rheinische Friedrich-Wilhelms-Universität Bonn Germany (DE) Martin-Luther-Universität Halle-Wittenberg (MLU) Germany (DE) Medizinisch Genetisches Zentrum (MGZ) / Medical Genetics Center Germany (DE) Universitätsklinikum Göttingen Germany (DE) Universitätsklinikum Leipzig Germany (DE) Universitätsklinikum Freiburg Germany (DE) Universitätsklinikum Köln Germany (DE) Klinikum rechts der Isar Germany (DE) Westfälische Wilhelms-Universität (WWU) Münster Germany (DE) Universitätsklinikum des Saarlandes (UKS) Germany (DE) Winkelwaldklinik Nordrach Germany (DE) Universitätsspital Basel Switzerland (CH) Deutsche Krebsgesellschaft (DKG) Germany (DE) AWMF-Institut für Medizinisches Wissensmanagement (AWMF-IMWi) Germany (DE) Ruhr-Universität Bochum (RUB) Germany (DE) Deutsche Rentenversicherung Germany (DE) Klinikum Harlaching Germany (DE) Krankenhaus Jerusalem Germany (DE) Steiermärkische Krankenanstaltengesellschaft m. b. H. LKH-Univ. Klinikum Graz Austria (AT) Universitätsklinikum Düsseldorf Germany (DE) Charité - Universitätsmedizin Berlin Germany (DE) Muldentalkliniken Germany (DE) Deutscher Verband für Physiotherapie (ZVK) e. V. Germany (DE) Universitätsklinikum Magdeburg A.ö.R. Germany (DE) Städtisches Klinikum Lüneburg Germany (DE) Universitätsklinikum Jena Germany (DE) HELIOS Kliniken Germany (DE) Frauenselbsthilfe nach Krebs - Bundesverband e. V. Germany (DE) Sana Klinikum Offenbach Germany (DE) St.-Johannes-Hospital Germany (DE) Klinikum Fürth Germany (DE) Vivantes - Netzwerk für Gesundheit GmbH Germany (DE) Universitätsklinikum Heidelberg Germany (DE) Medizinische Universität Innsbruck Austria (AT) Pius-Hospital Oldenburg Germany (DE) Martin-Luther-Krankenhaus Germany (DE) Medizinischer Dienst des Spitzenverbandes Bund der Krankenkassen e.V. (MDS) Germany (DE) Universitätsmedizin Greifswald / Universitätsklinikum Greifswald Germany (DE) Inselspital, Universitätsspital Bern Switzerland (CH) Ludwig-Maximilians-Universität (LMU) Germany (DE)

How to cite

APA:

Emons, G., Steiner, E., Vordermark, D., Uleer, C., Bock, N., Paradiess, K.,... Erdogan, S. (2018). Interdisciplinary Diagnosis, Therapy and Follow-up of Patients with Endometrial Cancer. Guideline (S3-Level, AWMF Registry Nummer 032/034-OL, April 2018) - Part 1 with Recommendations on the Epidemiology, Screening, Diagnosis and Hereditary Factors of Endometrial Cancer. Geburtshilfe und Frauenheilkunde, 78(10), 949-971. https://dx.doi.org/10.1055/a-0713-1218

MLA:

Emons, Guenter, et al. "Interdisciplinary Diagnosis, Therapy and Follow-up of Patients with Endometrial Cancer. Guideline (S3-Level, AWMF Registry Nummer 032/034-OL, April 2018) - Part 1 with Recommendations on the Epidemiology, Screening, Diagnosis and Hereditary Factors of Endometrial Cancer." Geburtshilfe und Frauenheilkunde 78.10 (2018): 949-971.

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