Acid sphingomyelinase controls dopamine activity and responses to appetitive stimuli in mice

Journal article


Publication Details

Author(s): Kalinichenko L, Hammad L, Reichel M, Kohl Z, Gulbins E, Kornhuber J, Müller CP
Journal: Brain Research Bulletin
Publication year: 2019
Volume: 146
Pages range: 310-319
ISSN: 0361-9230


Abstract

Alcohol use disorder and depression show a high comorbidity at clinical level with no treatment available selectively for this condition. A hyperfunction of acid sphingomyelinase (ASM) and resulting ceramide overload were recently identified as one pathway into this comorbidity. Here we analyzed the involvement of ASM, one of the main enzymes involved in ceramide synthesis, in the molecular control of monoaminergic systems in their basal activity and in response to pharmacological and natural reinforcers. The effects of alcohol and a palatable food on the extracellular levels of dopamine (DA), serotonin (5-HT), and noradrenaline (NE) were measured by in-vivo microdialysis in ASM overexpressing mice (tgASM). We found reduced basal extracellular DA levels in the nucleus accumbens (Nac) and dorsal hippocampus (DH) of tgASM mice with little effect on 5-HT and NE levels. In contrast, ASM overexpression potentiated the DA response to alcohol (2 g/kg, i.p.) in the DH and Nac, but reduced NE responses. DA and NE responses to a food stimulus were not altered in tgASM mice, but the Nac 5-HT response was enhanced.


FAU Authors / FAU Editors

Kalinichenko, Liubov
Professur für Suchtmedizin
Kohl, Zacharias PD Dr.
Medizinische Fakultät
Kornhuber, Johannes Prof. Dr. med.
Lehrstuhl für Psychiatrie und Psychotherapie
Müller, Christian P. Prof. Dr.
Professur für Suchtmedizin
Reichel, Martin PD Dr.
Psychiatrische und Psychotherapeutische Klinik


External institutions with authors

Universität Duisburg-Essen (UDE)


How to cite

APA:
Kalinichenko, L., Hammad, L., Reichel, M., Kohl, Z., Gulbins, E., Kornhuber, J., & Müller, C.P. (2019). Acid sphingomyelinase controls dopamine activity and responses to appetitive stimuli in mice. Brain Research Bulletin, 146, 310-319. https://dx.doi.org/10.1016/j.brainresbull.2019.01.026

MLA:
Kalinichenko, Liubov, et al. "Acid sphingomyelinase controls dopamine activity and responses to appetitive stimuli in mice." Brain Research Bulletin 146 (2019): 310-319.

BibTeX: 

Last updated on 2019-20-03 at 16:53

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