Effect of Trinucleotide Repeat Expansion on the Expression of TCF4 mRNA in Fuchs' Endothelial Corneal Dystrophy

Okumura N, Hayashi R, Nakano M, Yoshii K, Tashiro K, Sato T, Blake DJ, Aleff R, Butz M, Highsmith EW, Wieben ED, Fautsch MP, Baratz KH, Komori Y, Nakahara M, Tourtas T, Schlötzer-Schrehardt U, Kruse F, Koizumi N (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Investigative Ophthalmology & Visual Science Association for Research in Vision and Ophthalmology (ARVO)

Book Volume: 60

Pages Range: 779-786

Journal Issue: 2

DOI: 10.1167/iovs.18-25760

Abstract

PURPOSE. CTG trinucleotide repeat (TNR) expansion is frequently found in transcription factor 4 (TCF4) in Fuchs' endothelial corneal dystrophy (FECD), though the effect of TNR expansion on FECD pathophysiology remains unclear. The purpose of this study was to evaluate the effect of TNR expansion on TCF4 expression in corneal endothelium of patients with FECD.

Authors with CRIS profile

Ursula Schlötzer-Schrehardt Medizinische Fakultät Friedrich Kruse Lehrstuhl für Augenheilkunde

Involved external institutions

Doshisha University / 同志社大学

Japan (JP) Kyoto Prefectural University of Medicine / 京都府立医科大学

Japan (JP) Mayo Clinic

United States (USA) (US) Cardiff University

United Kingdom (GB)

How to cite

APA:

Okumura, N., Hayashi, R., Nakano, M., Yoshii, K., Tashiro, K., Sato, T.,... Koizumi, N. (2019). Effect of Trinucleotide Repeat Expansion on the Expression of TCF4 mRNA in Fuchs' Endothelial Corneal Dystrophy. Investigative Ophthalmology & Visual Science, 60(2), 779-786. https://dx.doi.org/10.1167/iovs.18-25760

MLA:

Okumura, Naoki, et al. "Effect of Trinucleotide Repeat Expansion on the Expression of TCF4 mRNA in Fuchs' Endothelial Corneal Dystrophy." Investigative Ophthalmology & Visual Science 60.2 (2019): 779-786.

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