Vitamin D attenuates rhinovirus-induced expression of intercellular adhesion molecule-1 (ICAM-1) and platelet-activating factor receptor (PAFR) in respiratory epithelial cells

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Greiller CL, Suri R, Jolliffe DA, Kebadze T, Hirsman AG, Griffiths CJ, Johnston SL, Martineau AR
Zeitschrift: Journal of Steroid Biochemistry and Molecular Biology
Jahr der Veröffentlichung: 2019
Band: 187
Seitenbereich: 152-159
ISSN: 0960-0760


Abstract

Human rhinoviruses commonly cause upper respiratory infections, which may be complicated by secondary bacterial infection. Vitamin D replacement reduces risk of acute respiratory infections in vitamin D-deficient individuals, but the mechanisms by which such protection is mediated are incompletely understood. We therefore conducted experiments to characterise the influence of the major circulating metabolite 25-hydroxyvitamin D (25[OH]D) and the active metabolite 1,25-dihydroxyvitamin D (1,25[OH](2)ZD) on responses of a respiratory epithelial cell line (A549 cells) to infection with a major group human rhinovirus (RV-16). Pretreatment of A549 respiratory epithelial cells with a physiological concentration (10(-7)M) of 25(OH)D induced transient resistance to infection with RV-16 and attenuated RV-16-induced expression of the genes encoding intercellular adhesion molecule 1 (ICAM-1, a cell surface glycoprotein that acts as the cellular receptor for major group rhinoviruses) and platelet-activating factor receptor (PAFR, a G-protein coupled receptor implicated in adhesion of Streptococcus pnettatorticte to respiratory epithelial cells). These effects were associated with enhanced expression of the genes encoding the NF-kappa B inhibitor I kappa 8 alpha and the antimicrobial peptide cathelicidin LL-37. Our findings suggest possible mechanisms by which vitamin D may enhance resistance to rhinovirus infection and reduce risk of secondary bacterial infection in vitamin D-deficient individuals.


Zusätzliche Organisationseinheit(en)
Transfusionsmedizinische und Hämostaseologische Abteilung in der Chirurgischen Klinik


Einrichtungen weiterer Autorinnen und Autoren

Imperial College London / The Imperial College of Science, Technology and Medicine
Queen Mary, University of London


Zitierweisen

APA:
Greiller, C.L., Suri, R., Jolliffe, D.A., Kebadze, T., Hirsman, A.G., Griffiths, C.J.,... Martineau, A.R. (2019). Vitamin D attenuates rhinovirus-induced expression of intercellular adhesion molecule-1 (ICAM-1) and platelet-activating factor receptor (PAFR) in respiratory epithelial cells. Journal of Steroid Biochemistry and Molecular Biology, 187, 152-159. https://dx.doi.org/10.1016/j.jsbmb.2018.11.013

MLA:
Greiller, Claire L., et al. "Vitamin D attenuates rhinovirus-induced expression of intercellular adhesion molecule-1 (ICAM-1) and platelet-activating factor receptor (PAFR) in respiratory epithelial cells." Journal of Steroid Biochemistry and Molecular Biology 187 (2019): 152-159.

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Zuletzt aktualisiert 2019-20-03 um 11:44