Radiochemotherapy for invasive bladder cancer : An update
Tselis N, Prott FJ, Ott O, Weiss C, Roedel C (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 57
Pages Range: 679-685
Journal Issue: 6
DOI: 10.1007/s00120-018-0628-0
Abstract
BACKGROUND: The standard treatment for muscle-invasive bladder cancer is radical cystectomy with pelvic lymphadenectomy. Primary organ-preservation by means of multimodal therapy, however, can be a viable alternative to radical surgery. OBJECTIVES: The concept and results of multimodal therapy, consisting of initial transurethral resection of the bladder tumor (TUR-B), followed by simultaneous radiochemotherapy (RCT), are presented. MATERIALS AND METHODS: Evaluation of retrospective cohorts and prospective therapy optimization studies on organ-preservation treatment regimens. Comparative meta-analyses comparing cystectomy with multimodal treatment are presented. RESULTS: Complete TUR-B, including bladder mapping and tumor biopsy, should precede simultaneous RCT. Radiosensitization should be cisplatin-based or consist of a combination of 5‑fluorouracil and mitomycin C. Complete response rates after TUR-B plus RCT are generated in 60-90% of patients along with 5‑year survival rates of 40-75% and preservation of the bladder in approximately 80% of surviving patients. CONCLUSIONS: Multimodal therapy by means of TUR-B followed by simultaneous RCT is a viable alternative to radical cystectomy for patients with muscle-invasive urinary bladder carcinoma. Patients with early tumors (cT2/3N0) are particularly suitable in whom initial TUR-B leads to complete tumor resection (R0).
Additional Organisation(s)
Involved external institutions
Klinikum Darmstadt
Germany (DE)
Universitätsklinikum Frankfurt am Main (KGU)
Germany (DE)
Goethe-Universität Frankfurt am Main
Germany (DE)
Germany (DE)
Universitätsklinikum Frankfurt am Main (KGU)
Germany (DE)
Goethe-Universität Frankfurt am Main
Germany (DE)
How to cite
APA:
Tselis, N., Prott, F.J., Ott, O., Weiss, C., & Roedel, C. (2018). Radiochemotherapy for invasive bladder cancer : An update. Urologe, 57(6), 679-685. https://dx.doi.org/10.1007/s00120-018-0628-0
MLA:
Tselis, N., et al. "Radiochemotherapy for invasive bladder cancer : An update." Urologe 57.6 (2018): 679-685.
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