WONOEP APPRAISAL: The many facets of epilepsy networks
Scott RC, De La Prida LM, Mahoney JM, Kobow K, Sankar R, De Curtis M (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 59
Pages Range: 1475-1483
Journal Issue: 8
DOI: 10.1111/epi.14503
Abstract
The brain is a complex system composed of networks of interacting elements, from genes to circuits, whose function (and dysfunction) is not derivable from the superposition of individual components. Epilepsy is frequently described as a network disease, but to date, there is no standardized framework within which network concepts applicable to all levels from genes to whole brain can be used to generate deeper insights into the pathogenesis of seizures or the associated morbidities. To address this shortcoming, the Neurobiology Commission of the International League Against Epilepsy dedicated a Workshop on Neurobiology of Epilepsy (XIV WONOEP 2017) with the aim of formalizing network concepts as they apply to epilepsy and to critically discuss whether and how such concepts could augment current research endeavors. Here, we review concepts and strategies derived by considering epilepsy as a disease of different network hierarchies that range from genes to clinical phenotypes. We propose that the concept of networks is important for understanding epilepsy and is critical for developing new study designs. These approaches could ultimately facilitate the development of novel diagnostic and therapeutic strategies.
Authors with CRIS profile
Additional Organisation(s)
Involved external institutions
Foundation of the Carlo Besta Neurological Institute (IRCCS)
Italy (IT)
University of California Los Angeles (UCLA)
United States (USA) (US)
University of Vermont
United States (USA) (US)
Spanish National Research Council / Consejo Superior de Investigaciones Científicas (CSIC)
Spain (ES)
Italy (IT)
University of California Los Angeles (UCLA)
United States (USA) (US)
University of Vermont
United States (USA) (US)
Spanish National Research Council / Consejo Superior de Investigaciones Científicas (CSIC)
Spain (ES)
How to cite
APA:
Scott, R.C., De La Prida, L.M., Mahoney, J.M., Kobow, K., Sankar, R., & De Curtis, M. (2018). WONOEP APPRAISAL: The many facets of epilepsy networks. Epilepsia, 59(8), 1475-1483. https://dx.doi.org/10.1111/epi.14503
MLA:
Scott, Rod C., et al. "WONOEP APPRAISAL: The many facets of epilepsy networks." Epilepsia 59.8 (2018): 1475-1483.
BibTeX: Download