Motor neuron diseases. Clinical and genetic differential diagnostics

Regensburger M, Weidner N, Kohl Z (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Der Nervenarzt Springer

Book Volume: 89

Pages Range: 658-665

Journal Issue: 6

DOI: 10.1007/s00115-018-0524-2

Abstract

The causes of degenerative disease of the upper and lower motor neurons are incompletely understood. In this review the current concepts in the clinical and genetic differential diagnostics of motor neuron diseases are presented. Hereditary spastic paraplegia, primary lateral sclerosis, spinal muscular atrophy and amyotrophic lateral sclerosis are explained, structured according to the affection of the upper and/or lower motor neuron. The substantial variability in the presentation and course of motor neuron diseases as well as the lack of specific laboratory tests hinder an early diagnosis. The precise description of the clinical picture, thorough testing of possible differential diagnoses as well as monitoring of the clinical course are essential. Genetic analyses should be offered to patients with a positive family history. Early identification of clinical and genetic subentities of the individual motor neuron diseases is a prerequisite for future neuroprotective interventions.

Authors with CRIS profile

Martin Regensburger Department of Neurology Zacharias Kohl Department of Molecular Neurology

Involved external institutions

Universitätsklinikum Heidelberg DE Germany (DE)

How to cite

APA:

Regensburger, M., Weidner, N., & Kohl, Z. (2018). Motor neuron diseases. Clinical and genetic differential diagnostics. Der Nervenarzt, 89(6), 658-665. https://dx.doi.org/10.1007/s00115-018-0524-2

MLA:

Regensburger, Martin, N. Weidner, and Zacharias Kohl. "Motor neuron diseases. Clinical and genetic differential diagnostics." Der Nervenarzt 89.6 (2018): 658-665.

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