FDG-PET underscores the key role of the thalamus in frontotemporal lobar degeneration caused by C9ORF72 mutations

Journal article


Publication Details

Author(s): Diehl-Schmid J, Licata A, Goldhardt O, Foerstl H, Yakushew I, Otto M, Anderl-Straub S, Beer A, Ludolph AC, Landwehrmeyer GB, Levin J, Danek A, Fliessbach K, Spottke A, Fassbender K, Lyros E, Prudlo J, Krause BJ, Volk A, Edbauer D, Schroeter ML, Drzezga A, Kornhuber J, Lauer M, Ackl N, Arnim CV, Brumberg J, Gaertner F, Jahn H, Kasper E, Kassubek J, Prix C, Riedl L, Rossmeier C, Schoenecker S, Semler E, Teipel S, Westerteicher C, Wlasich E, Grimmer T
Journal: Translational Psychiatry
Publication year: 2019
Volume: 9
ISSN: 2158-3188


Abstract

C9ORF72 mutations are the most common cause of familial frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). MRI studies have investigated structural changes in C9ORF72-associated FTLD (C9FTLD) and provided first insights about a prominent involvement of the thalamus and the cerebellum. Our multicenter, F-18-fluorodeoxyglucose positron-emission tomography study of 22 mutation carriers with FTLD, 22 matched non-carriers with FTLD, and 23 cognitively healthy controls provided valuable insights into functional changes in C9FTLD: compared to non-carriers, mutation carriers showed a significant reduction of glucose metabolism in both thalami, underscoring the key role of the thalamus in C9FTLD. Thalamic metabolism did not correlate with disease severity, duration of disease, or the presence of psychotic symptoms. Against our expectations we could not demonstrate a cerebellar hypometabolism in carriers or non-carriers. Future imaging and neuropathological studies in large patient cohorts are required to further elucidate the central role of the thalamus in C9FTLD.


FAU Authors / FAU Editors

Kornhuber, Johannes Prof. Dr. med.
Lehrstuhl für Psychiatrie und Psychotherapie


External institutions with authors

Berufsgenossenschaftlichen Kliniken Bergmannstrost Halle
Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE)
Ludwig-Maximilians-Universität (LMU)
Rheinische Friedrich-Wilhelms-Universität Bonn
Technische Universität München (TUM)
Universität des Saarlandes (UdS)
Universität Köln
Universität Rostock
Universitätsklinikum Hamburg-Eppendorf (UKE)
Universitätsklinikum Leipzig
Universitätsklinikum Ulm
Universitätsklinikum Würzburg
Universitätsklinikum Würzburg


How to cite

APA:
Diehl-Schmid, J., Licata, A., Goldhardt, O., Foerstl, H., Yakushew, I., Otto, M.,... Grimmer, T. (2019). FDG-PET underscores the key role of the thalamus in frontotemporal lobar degeneration caused by C9ORF72 mutations. Translational Psychiatry, 9. https://dx.doi.org/10.1038/s41398-019-0381-1

MLA:
Diehl-Schmid, Janine, et al. "FDG-PET underscores the key role of the thalamus in frontotemporal lobar degeneration caused by C9ORF72 mutations." Translational Psychiatry 9 (2019).

BibTeX: 

Last updated on 2019-20-03 at 11:23