Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry

Journal article


Publication Details

Author(s): Lewczuk P, Riederer P, O'Bryant SE, Verbeek MM, Dubois B, Visser PJ, Jellinger KA, Engelborghs S, Ramirez A, Parnetti L, Jack CR, Teunissen CE, Hampel H, Lleo A, Jessen F, Glodzik L, De Leon MJ, Fagan AM, Luis Molinuevo J, Jansen WJ, Winblad B, Shaw LM, Andreasson U, Otto M, Mollenhauer B, Wiltfang J, Turner MR, Zerr I, Handels R, Thompson AG, Johansson G, Ermann N, Trojanowski JQ, Karaca I, Wagner H, Oeckl P, Van Doorn LVW, Bjerke M, Kapogiannis D, Kuiperij HB, Farotti L, Li Y, Gordon BA, Epelbaum S, Vos SJB, Klijn CJM, Van Nostrand WE, Minguillon C, Schmitz M, Gallo C, Mato AL, Thibaut F, Lista S, Alcolea D, Zetterberg H, Blennow K, Kornhuber J
Journal: World Journal of Biological Psychiatry
Publication year: 2018
Volume: 19
Journal issue: 4
Pages range: 244-328
ISSN: 1562-2975


Abstract

In the 12 years since the publication of the first Consensus Paper of the WFSBP on biomarkers of neurodegenerative dementias, enormous advancement has taken place in the field, and the Task Force takes now the opportunity to extend and update the original paper. New concepts of Alzheimer's disease (AD) and the conceptual interactions between AD and dementia due to AD were developed, resulting in two sets for diagnostic/research criteria. Procedures for pre-analytical sample handling, biobanking, analyses and post-analytical interpretation of the results were intensively studied and optimised. A global quality control project was introduced to evaluate and monitor the inter-centre variability in measurements with the goal of harmonisation of results. Contexts of use and how to approach candidate biomarkers in biological specimens other than cerebrospinal fluid (CSF), e.g. blood, were precisely defined. Important development was achieved in neuroimaging techniques, including studies comparing amyloid-β positron emission tomography results to fluid-based modalities. Similarly, development in research laboratory technologies, such as ultra-sensitive methods, raises our hopes to further improve analytical and diagnostic accuracy of classic and novel candidate biomarkers. Synergistically, advancement in clinical trials of anti-dementia therapies energises and motivates the efforts to find and optimise the most reliable early diagnostic modalities. Finally, the first studies were published addressing the potential of cost-effectiveness of the biomarkers-based diagnosis of neurodegenerative disorders.


FAU Authors / FAU Editors

Ermann, Natalia
Medizinische Fakultät
Kornhuber, Johannes Prof. Dr. med.
Lehrstuhl für Psychiatrie und Psychotherapie
Lewczuk, Piotr Prof. Dr.
Psychiatrische und Psychotherapeutische Klinik


External institutions
Autonomous University of Barcelona (UAB) / Universitat Autònoma de Barcelona
Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE)
Free University Medical Center / VU Medisch Centrum
Georg-August-Universität Göttingen
Hôpital Cochin
Karolinska Institute
Maastricht University
Mayo Clinic
Medizinische Universität Wien
National Institute on Aging (NIA)
NYU Langone Medical Center
Paracelsus-Elena-Klinik Kassel
Pasqual Maragall Foundation
Radboud University Nijmegen
Rheinische Friedrich-Wilhelms-Universität Bonn
Sahlgrenska University Hospital / Sahlgrenska Universitetssjukhuset
State University of New York (SUNY) Stony Brook
Universidad Maimónides
Universidad Peruana Cayetano Heredia
Università degli Studi di Perugia
Universität Köln
Universitätsklinikum Würzburg
Universität Ulm
Université Pierre et Marie Curie (UPMC, Sorbonne 6)
University of Antwerp / Universiteit Antwerpen
University of North Texas (UNT)
University of Oxford
University of Pennsylvania
Washington University


How to cite

APA:
Lewczuk, P., Riederer, P., O'Bryant, S.E., Verbeek, M.M., Dubois, B., Visser, P.J.,... Kornhuber, J. (2018). Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry. World Journal of Biological Psychiatry, 19(4), 244-328. https://dx.doi.org/10.1080/15622975.2017.1375556

MLA:
Lewczuk, Piotr, et al. "Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry." World Journal of Biological Psychiatry 19.4 (2018): 244-328.

BibTeX: 

Last updated on 2019-12-03 at 09:08