Bacterial coinfection restrains antiviral CD8 T-cell response via LPS-induced inhibitory NK cells

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Straub T, Freudenberg MA, Schleicher U, Bogdan C, Gasteiger G, Pircher H
Zeitschrift: Nature Communications
Jahr der Veröffentlichung: 2018
Band: 9
Heftnummer: 1
ISSN: 2041-1723


Abstract

Infection of specific pathogen-free mice with lymphocytic choriomeningitis virus (LCMV) is a widely used model to study antiviral T-cell immunity. Infections in the real world, however, are often accompanied by coinfections with unrelated pathogens. Here we show that in mice, systemic coinfection with E. coli suppresses the LCMV-specific cytotoxic T-lymphocyte (CTL) response and virus elimination in a NK cell- and TLR2/4-dependent manner. Soluble TLR4 ligand LPS also induces NK cell-mediated negative CTL regulation during LCMV infection. NK cells in LPS-treated mice suppress clonal expansion of LCMV-specific CTLs by a NKG2D- or NCR1-independent but perforin-dependent mechanism. These results suggest a TLR4-mediated immunoregulatory role of NK cells during viral-bacterial coinfections.


FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Bogdan, Christian Prof. Dr.
Lehrstuhl für Mikrobiologie und Infektionsimmunologie
Schleicher, Ulrike PD Dr.
Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene


Einrichtungen weiterer Autorinnen und Autoren

Albert-Ludwigs-Universität Freiburg
Julius-Maximilians-Universität Würzburg


Zitierweisen

APA:
Straub, T., Freudenberg, M.A., Schleicher, U., Bogdan, C., Gasteiger, G., & Pircher, H. (2018). Bacterial coinfection restrains antiviral CD8 T-cell response via LPS-induced inhibitory NK cells. Nature Communications, 9(1). https://dx.doi.org/10.1038/s41467-018-06609-z

MLA:
Straub, Tobias, et al. "Bacterial coinfection restrains antiviral CD8 T-cell response via LPS-induced inhibitory NK cells." Nature Communications 9.1 (2018).

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Zuletzt aktualisiert 2019-11-03 um 08:10