Bacterial coinfection restrains antiviral CD8 T-cell response via LPS-induced inhibitory NK cells

Straub T, Freudenberg MA, Schleicher U, Bogdan C, Gasteiger G, Pircher H (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Nature Communications Nature Publishing Group: Nature Communications

Book Volume: 9

Journal Issue: 1

DOI: 10.1038/s41467-018-06609-z

Abstract

Infection of specific pathogen-free mice with lymphocytic choriomeningitis virus (LCMV) is a widely used model to study antiviral T-cell immunity. Infections in the real world, however, are often accompanied by coinfections with unrelated pathogens. Here we show that in mice, systemic coinfection with E. coli suppresses the LCMV-specific cytotoxic T-lymphocyte (CTL) response and virus elimination in a NK cell- and TLR2/4-dependent manner. Soluble TLR4 ligand LPS also induces NK cell-mediated negative CTL regulation during LCMV infection. NK cells in LPS-treated mice suppress clonal expansion of LCMV-specific CTLs by a NKG2D- or NCR1-independent but perforin-dependent mechanism. These results suggest a TLR4-mediated immunoregulatory role of NK cells during viral-bacterial coinfections.

Authors with CRIS profile

Ulrike Schleicher Institute of Microbiology – Clinical Microbiology, Immunology and Hygiene Christian Bogdan Lehrstuhl für Mikrobiologie und Infektionsimmunologie

Involved external institutions

Albert-Ludwigs-Universität Freiburg DE Germany (DE) Julius-Maximilians-Universität Würzburg DE Germany (DE)

How to cite

APA:

Straub, T., Freudenberg, M.A., Schleicher, U., Bogdan, C., Gasteiger, G., & Pircher, H. (2018). Bacterial coinfection restrains antiviral CD8 T-cell response via LPS-induced inhibitory NK cells. Nature Communications, 9(1). https://dx.doi.org/10.1038/s41467-018-06609-z

MLA:

Straub, Tobias, et al. "Bacterial coinfection restrains antiviral CD8 T-cell response via LPS-induced inhibitory NK cells." Nature Communications 9.1 (2018).

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