beta-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration

Journal article

Publication Details

Author(s): Lodygin D, Hermann M, Schweingruber N, Flügel-Koch C, Watanabe T, Schlosser C, Merlini A, Korner H, Chang HF, Fischer HJ, Reichardt HM, Zagrebelsky M, Mollenhauer B, Kuegler S, Fitzner D, Frahm J, Stadelmann C, Haberl M, Odoardi F, Fluegel A
Journal: Nature
Publication year: 2019
Volume: 566
Journal issue: 7745
Pages range: 503-+
ISSN: 0028-0836
eISSN: 1476-4687


The grey matter is a central target of pathological processes in neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. The grey matter is often also affected in multiple sclerosis, an autoimmune disease of the central nervous system. The mechanisms that underlie grey matter inflammation and degeneration in multiple sclerosis are not well understood. Here we show that, in Lewis rats, T cells directed against the neuronal protein beta-synuclein specifically invade the grey matter and that this is accompanied by the presentation of multifaceted clinical disease. The expression pattern of beta-synuclein induces the local activation of these T cells and, therefore, determined inflammatory priming of the tissue and targeted recruitment of immune cells. The resulting inflammation led to significant changes in the grey matter, which ranged from gliosis and neuronal destruction to brain atrophy. In humans, beta-synuclein-specific T cells were enriched in patients with chronic-progressive multiple sclerosis. These findings reveal a previously unrecognized role of beta-synuclein in provoking T-cell-mediated pathology of the central nervous system.

FAU Authors / FAU Editors

Flügel-Koch, Cassandra Prof. Dr.
Medizinische Fakultät

External institutions with authors

Max-Planck-Institut für biophysikalische Chemie (Karl-Friedrich-Bonhoeffer-Institut) / Max Planck Institute for Biophysical Chemistry
Paracelsus-Elena-Klinik Kassel
Technische Universität Braunschweig
Universitätsklinikum Göttingen

How to cite

Lodygin, D., Hermann, M., Schweingruber, N., Flügel-Koch, C., Watanabe, T., Schlosser, C.,... Fluegel, A. (2019). beta-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration. Nature, 566(7745), 503-+.

Lodygin, Dmitri, et al. "beta-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration." Nature 566.7745 (2019): 503-+.


Last updated on 2019-11-03 at 23:08