Intra- and Postoperative Blood Flow Monitoring in a Sheep Model of Uterus Transplantation

Journal article


Publication Details

Author(s): Kengelbach-Weigand A, Lotz L, Schmid R, Lang W, Beckmann M, Hoffmann I, Horch RE, Renner S, Dittrich R, Boos A, Hildebrandt T
Journal: In Vivo
Publication year: 2019
Volume: 33
Journal issue: 2
Pages range: 325-336
ISSN: 0258-851X


Abstract

Background: The introduction of the opportunity to transplant a viable uterus into women for fulfilling their desire to have a child has awakened high expectations worldwide. Materials and Methods: A sheep model was used to evaluate tools for optimizing measurement of blood flow in uterine transplantation. Intraoperatively, blood flow was measured using unidirectional Doppler and indocyanine green (ICG) fluorescence imaging. Postoperatively, an implantable Doppler probe served as a tool for clinical monitoring the patency of anastomosed vessels. Results: ICG imaging showed complete vascularization of the uterus before and in short-term evaluation after surgery. The implantable Doppler probe proved to be highly suitable for assessing patency of vessels in a non-invasive way. Results of histology, and real-time polymerase chain reaction demonstrated viability of the transplanted uterus. Conclusion: Different methods to monitor vasculature patency have proven to be advantageous in supporting both surgeons and researchers in ensuring successful implementation of uterine transplantation.


FAU Authors / FAU Editors

Beckmann, Matthias Prof. Dr.
Lehrstuhl für Geburtshilfe und Frauenheilkunde
Boos, Anja Dr.
Plastisch- und Handchirurgische Klinik
Dittrich, Ralf Prof. Dr.
Professur für Experimentelle Reproduktionsmedizin
Horch, Raymund E. Prof. Dr.
Professur für Plastische Chirurgie und Handchirurgie
Kengelbach-Weigand, Annika Dr.
Plastisch- und Handchirurgische Klinik
Lang, Werner apl. Prof. Dr.
Gefäßchirurgische Abteilung
Lotz, Laura
Professur für Experimentelle Reproduktionsmedizin
Renner, Stefan Prof. Dr.
Medizinische Fakultät


How to cite

APA:
Kengelbach-Weigand, A., Lotz, L., Schmid, R., Lang, W., Beckmann, M., Hoffmann, I.,... Hildebrandt, T. (2019). Intra- and Postoperative Blood Flow Monitoring in a Sheep Model of Uterus Transplantation. In Vivo, 33(2), 325-336. https://dx.doi.org/10.21873/invivo.11478

MLA:
Kengelbach-Weigand, Annika, et al. "Intra- and Postoperative Blood Flow Monitoring in a Sheep Model of Uterus Transplantation." In Vivo 33.2 (2019): 325-336.

BibTeX: 

Last updated on 2019-25-03 at 11:23