Varus thrust during walking and the risk of incident and worsening medial tibiofemoral MRI lesions: the Multicenter Osteoarthritis Study

Wink AE, Gross KD, Brown CA, Guermazi A, Roemer F, Niu J, Torner J, Lewis CE, Nevitt MC, Tolstykh I, Sharma L, Felson DT (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Osteoarthritis and Cartilage Elsevier

Book Volume: 25

Pages Range: 839-845

Journal Issue: 6

DOI: 10.1016/j.joca.2017.01.005

Abstract

OBJECTIVE: To determine the association of varus thrust during walking to incident and worsening medial tibiofemoral cartilage damage and bone marrow lesions (BMLs) over 2 years in older adults with or at risk for osteoarthritis (OA). METHOD: Subjects from the Multicenter Osteoarthritis Study (MOST) were studied. Varus thrust was visually assessed from high-speed videos of forward walking trials. Baseline and two-year MRIs were acquired from one knee per subject and read for cartilage loss and BMLs. Logistic regression with generalized estimating equations was used to estimate the odds of incident and worsening cartilage loss and BMLs, adjusting for age, sex, race, body mass index (BMI), and clinic site. The analysis was repeated stratified by varus, neutral, and valgus alignment. RESULTS: 1007 participants contributed one knee each. Varus thrust was observed in 29.9% of knees. Knees with thrust had 2.17 [95% CI: 1.51, 3.11] times the odds of incident medial BML, 2.51 [1.85, 3.40] times the odds of worsening medial BML, and 1.85 [1.35, 2.55] times the odds of worsening medial cartilage loss. When stratified by alignment, varus knees also had significantly increased odds of these outcomes. CONCLUSION: Varus thrust observed during walking is associated with increased odds of incident and worsening medial BMLs and worsening medial cartilage loss. Increased odds of these outcomes persist in varus-aligned knees.

Authors with CRIS profile

Frank Roemer Institute of Radiology

Involved external institutions

University of California San Francisco (UCSF) US United States (USA) (US) Boston University US United States (USA) (US) University of Iowa US United States (USA) (US) University of Alabama at Birmingham (UAB) US United States (USA) (US) Northwestern University US United States (USA) (US)

How to cite

APA:

Wink, A.E., Gross, K.D., Brown, C.A., Guermazi, A., Roemer, F., Niu, J.,... Felson, D.T. (2017). Varus thrust during walking and the risk of incident and worsening medial tibiofemoral MRI lesions: the Multicenter Osteoarthritis Study. Osteoarthritis and Cartilage, 25(6), 839-845. https://doi.org/10.1016/j.joca.2017.01.005

MLA:

Wink, A. E., et al. "Varus thrust during walking and the risk of incident and worsening medial tibiofemoral MRI lesions: the Multicenter Osteoarthritis Study." Osteoarthritis and Cartilage 25.6 (2017): 839-845.

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