Non-invasive bladder cancer

Burger M, Schwaibold H, Goebell P, Grimm MO (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Onkologe Springer Verlag (Germany)

Book Volume: 24

Pages Range: 23-31

Journal Issue: 1

Abstract

Background. Non-muscle-invasive bladder cancer is a common cancer entity demanding complex diagnostics and treatment. Aim. This review presents the current state of the art of the diagnostics and treatment with an emphasis on risk-adapted patient management. Material and methods. This review is based on a literature search in PubMed for sources on the etiology, diagnostics, treatment and risk-adapted patient management of non-muscle-invasive bladder cancer. Results. Non-muscle-invasive bladder cancer mainly becomes clinically apparent with painless macrohematuria. Only cystoscopy can lead to a sufficiently sound diagnosis, whereas no urinary markers providing reliable accuracy exist. Treatment usually starts with transurethral resection of the bladder tumor providing histopathological verification of the diagnosis and a basis for further treatment: in some cases it is the only treatment necessary. Histopathology guides further decision-making and provides a clear risk stratification by using some simple clinical and cystoscopical parameters. In low-risk cases transurethral resection with a single adjuvant instillation therapy early after surgery suffices, in intermediate-risk cases further outpatient instillations with a chemotherapeutic agent or bacillus Calmette-Gu,rin (BCG) follow and in high-risk cases resection is followed by repeat resection and BCG; however, cystectomy also has to be considered. In all cases a structured follow-up is mandatory. Conclusion. Despite high recurrence rates and in high-risk cases also substantial progression rates of non-muscle-invasive bladder cancer, a relatively good prognosis concerning recurrence and an advantageous prognosis concerning cancer-specific survival can be achieved using all currently available possibilities.

Authors with CRIS profile

Peter Goebell Urologische Klinik

Involved external institutions

Universität Regensburg DE Germany (DE) Klinikum am Steinenberg Reutlingen DE Germany (DE) Universitätsklinikum Jena DE Germany (DE)

How to cite

APA:

Burger, M., Schwaibold, H., Goebell, P., & Grimm, M.-O. (2018). Non-invasive bladder cancer. Onkologe, 24(1), 23-31.

MLA:

Burger, Maximilian, et al. "Non-invasive bladder cancer." Onkologe 24.1 (2018): 23-31.

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