No Evidence That Genetic Variation in the Myeloid-Derived Suppressor Cell Pathway Influences Ovarian Cancer Survival

Journal article


Publication Details

Author(s): Sucheston-Campbell LE, Cannioto R, Clay AI, Etter JL, Eng KH, Liu S, Battaglia S, Hu Q, Szender JB, Minlikeeva A, Joseph JM, Mayor P, Abrams SI, Segal BH, Wallace PK, Soh KT, Zsiros E, Anton-Culver H, Bandera EV, Beckmann M, Berchuck A, Bjorge L, Bruegl A, Campbell IG, Campbell SP, Chenevix-Trench G, Cramer DW, Dansonka-Mieszkowska A, Dao F, Diergaarde B, Doerk T, Doherty JA, Du Bois A, Eccles D, Engelholm SA, Fasching P, Gayther SA, Gentry-Maharaj A, Glasspool RM, Goodman MT, Gronwald J, Harter P, Hein A, Heitz F, Hillemmanns P, Hogdall C, Hogdall EVS, Huzarski T, Jensen A, Johnatty SE, Jung A, Karlan BY, Klapdor R, Kluz T, Konopka B, Kjaer SK, Kupryjanczyk J, Lambrechts D, Lester J, Lubinski J, Levine DA, Lundvall L, Mcguire V, Mcneish IA, Menon U, Modugno F, Ness RB, Orsulic S, Paul J, Pearce CL, Pejovic T, Pharoah P, Ramus SJ, Rothstein J, Rossing MA, Rübner M, Schildkraut JM, Schmalfeldt B, Schwaab I, Siddiqui N, Sieh W, Sobiczewski P, Song H, Terry KL, Van Nieuwenhuysen E, Vanderstichele A, Vergote I, Walsh CS, Webb PM, Wentzensen N, Whittemore AS, Wu AH, Ziogas A, Odunsi K, Chang-Claude J, Goode EL, Moysich KB
Journal: Cancer Epidemiology Biomarkers & Prevention
Publication year: 2017
Volume: 26
Journal issue: 3
Pages range: 420-424
ISSN: 1055-9965


Abstract

Background: The precise mechanism by which the immune system is adversely affected in cancer patients remains poorly understood, but the accumulation of immunosuppressive/protumorigenic myeloid-derived suppressor cells (MDSCs) is thought to be a prominent mechanism contributing to immunologic tolerance of malignant cells in epithelial ovarian cancer (EOC). To this end, we hypothesized genetic variation in MDSC pathway genes would be associated with survival after EOC diagnoses.Methods: We measured the hazard of death due to EOC within 10 years of diagnosis, overall and by invasive subtype, attributable to SNPs in 24 genes relevant in the MDSC pathway in 10,751 women diagnosed with invasive EOC. Versatile Gene-based Association Study and the admixture likelihood method were used to test gene and pathway associations with survival.Results: We did not identify individual SNPs that were significantly associated with survival after correction for multiple testing (P < 3.5 × 10-5), nor did we identify significant associations between the MDSC pathway overall, or the 24 individual genes and EOC survival.Conclusions: In this well-powered analysis, we observed no evidence that inherited variations in MDSC-associated SNPs, individual genes, or the collective genetic pathway contributed to EOC survival outcomes.Impact: Common inherited variation in genes relevant to MDSCs was not associated with survival in women diagnosed with invasive EOC. Cancer Epidemiol Biomarkers Prev; 26(3); 420-4. ©2016 AACR.


FAU Authors / FAU Editors

Beckmann, Matthias Prof. Dr.
Lehrstuhl für Geburtshilfe und Frauenheilkunde
Fasching, Peter PD Dr.
Professur für Translationale Frauenheilkunde und Geburtshilfe
Hein, Alexander PD Dr.
Frauenklinik
Rübner, Matthias PD Dr.
Frauenklinik


External institutions with authors

Beatson West of Scotland Cancer Centre (BWSCC)
Brigham and Women's Hospital (BWH)
Cedars-Sinai Medical Center
Danish Cancer Society Research Center
Dartmouth College
Deutsches Krebsforschungszentrum (DKFZ)
Duke University Medical Center
Fred Hutchinson Cancer Research Center
Glasgow Royal Infirmary (GRI)
Haukeland University Hospital / Haukeland universitetssykehus
Icahn School of Medicine at Mount Sinai
Katholieke Universiteit Leuven (KUL) / Catholic University of Leuven
Kliniken Essen-Mitte
Maria Skłodowska-Curie Institute of Oncology / Centrum Onkologii–Instytut im. Marii Skłodowskiej-Curie w Warszawie
Mayo Clinic
Medizinische Hochschule Hannover (MHH) / Hannover Medical School
National Cancer Institute (NCI)
NYU Langone Medical Center
Ohio State University
Oregon Health and Science University (OSHU)
Pomeranian Medical University / Pomorski Uniwersytet Medyczny w Szczecinie (PMU)
QIMR Berghofer Medical Research Institute (früher: the Queensland Institute of Medical Research)
Roswell Park Cancer Institute
Rutgers Cancer Institute of New Jersey
Stanford University
The University of Melbourne
Universitätsklinikum Hamburg-Eppendorf (UKE)
University College London (UCL)
University Hospital Leuven (UZ) / Universitaire ziekenhuizen Leuven
University of California Irvine
University of Cambridge
University of Copenhagen
University of Glasgow
University of Michigan
University of New South Wales (UNSW)
University of Pittsburgh
University of Southampton
University of Southern California (USC)
University of Texas Health Science Center at Houston (UTHealth)
University of Virginia (UVA)
Uniwersytet Rzeszowski


How to cite

APA:
Sucheston-Campbell, L.E., Cannioto, R., Clay, A.I., Etter, J.L., Eng, K.H., Liu, S.,... Moysich, K.B. (2017). No Evidence That Genetic Variation in the Myeloid-Derived Suppressor Cell Pathway Influences Ovarian Cancer Survival. Cancer Epidemiology Biomarkers & Prevention, 26(3), 420-424. https://dx.doi.org/10.1158/1055-9965.EPI-16-0631

MLA:
Sucheston-Campbell, Lara E., et al. "No Evidence That Genetic Variation in the Myeloid-Derived Suppressor Cell Pathway Influences Ovarian Cancer Survival." Cancer Epidemiology Biomarkers & Prevention 26.3 (2017): 420-424.

BibTeX: 

Last updated on 2019-26-03 at 08:38