Cu-Releasing Bioactive Glass Coatings and Their in Vitro Properties

Beitrag in einer Fachzeitschrift

Details zur Publikation

Autorinnen und Autoren: Rau JV, Curcio M, Raucci MG, Barbaro K, Fasolino I, Teghil R, Ambrosio L, De Bonis A, Boccaccini AR
Zeitschrift: ACS Applied Materials and Interfaces
Jahr der Veröffentlichung: 2019
Band: 11
Heftnummer: 6
Seitenbereich: 5812-5820
ISSN: 1944-8244


Bioactive glasses are well-known materials suitable for bone-related applications thanks to their biocompatibility and osteoconductivity. In order to improve their in vivo performance, the modification of the glass composition by adding ions with specific biological functions is required. As copper (Cu) possesses antibacterial properties, in this study, 5 wt % of CuO has been added to the 45S5 bioactive glass composition. The investigation of the effect of the Cu-containing bioactive glass on cellular behavior has revealed that the presence of Cu induces an early differentiation of human mesenchymal stem cells through osteoblast phenotype, Target la earn promotes the expression of anti-inflammatory interleukin, and reduces proinflammatory interleukin expression. With the aim to produce coatings with antibacterial properties, the Cu-containing bioactive glass was used as the target material for the pulsed laser deposition (PLD) of bioactive thin films. PLD experiments were carried out at different substrate temperatures to study the effect on the film's characteristics. All of the films are compact, crack-free, and characterized by a rough morphology and good wettability. The in vitro bioactivity was demonstrated by the apatite growth on the coating surface, after soaking in simulated body fluid, revealed by Raman spectroscopy and scanning electron microscopy-energy dispersive X-ray analyses. The antibacterial study proved that the material showed more effective activity against three Gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli, Salmonella enterica) rather than against Gram-positive bacteria (Staphylococcus aureus).

FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Boccaccini, Aldo R. Prof. Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Einrichtungen weiterer Autorinnen und Autoren

Consiglio Nazionale delle Ricerche (CNR)
Università degli Studi della Basilicata


Rau, J.V., Curcio, M., Raucci, M.G., Barbaro, K., Fasolino, I., Teghil, R.,... Boccaccini, A.R. (2019). Cu-Releasing Bioactive Glass Coatings and Their in Vitro Properties. ACS Applied Materials and Interfaces, 11(6), 5812-5820.

Rau, Julietta V., et al. "Cu-Releasing Bioactive Glass Coatings and Their in Vitro Properties." ACS Applied Materials and Interfaces 11.6 (2019): 5812-5820.


Zuletzt aktualisiert 2019-20-03 um 11:53