A COMPARISON BETWEEN 6-POINT DIXON MRI AND MR SPECTROSCOPY TO QUANTIFY MUSCLE FAT IN THE THIGH OF SUBJECTS WITH SARCOPENIA

Journal article


Publication Details

Author(s): Grimm A, Meyer H, Nickel MD, Nittka M, Raithel E, Chaudry O, Friedberger A, Uder M, Kemmler W, Engelke K, Quick HH
Journal: Journal of Frailty & Aging
Publication year: 2019
Volume: 8
Journal issue: 1
Pages range: 21-26
ISSN: 2260-1341
eISSN: 2273-4309


Abstract

Background: Changes in muscle fat composition as for example observed in sarcopenia, affect physical performance and muscular function, like strength and power. Objectives: The purpose of this study was to compare 6-point Dixon magnetic resonance imaging and multi-echo magnetic resonance spectroscopy sequences to quantify muscle fat. Setting, participants and measurements: Two groups were recruited (G1: 23 healthy young men (28 +/- 4 years), G2: 56 men with sarcopenia (80 +/- 5 years)). Proton density fat fraction was measured with a 6-point product and a 6-point prototype Dixon sequence in the left thigh muscle and with a highspeed multi-echo T2*-corrected H1 magnetic resonance spectroscopy sequence within the semitendinosus muscle of the left thigh. To evaluate the comparability among the different methods, Bland-Altman and linear regression analyses of the proton density fat fraction results were performed. Results: Mean differences +/- 1.96 * standard deviation between spectroscopy and 6pt Dixon sequences were 1.9 +/- 3.3% and 1.5 +/- 3.6% for the product and prototype sequences, respectively. High correlations were measured between the proton density fat fraction results of the 6-point Dixon sequences and spectroscopy (R = 0.95 for the product sequence and R = 0.97 for the prototype sequence). Conclusions: Dixon imaging and spectroscopy sequences show comparable accuracy for fat measurements in the thigh. Spectroscopy is a local measurement, whereas Dixon sequences provide maps of the fat distribution. The high correlations of the 6-point Dixon sequences with spectroscopy support their clinical use. They provide higher spatial resolution than spectroscopy, but are not suitable for a more complicated spectral analysis to separate extra-and intramyocellular lipids.


FAU Authors / FAU Editors

Chaudry, Oliver
Medizinische Fakultät
Engelke, Klaus Prof. Dr.
Lehrstuhl für Medizinische Physik
Friedberger, Andreas
Lehrstuhl für Medizinische Physik
Grimm, Alexandra
Lehrstuhl für Medizinische Physik
Kemmler, Wolfgang Prof. Dr.
Lehrstuhl für Medizinische Physik
Uder, Michael Prof. Dr.
Lehrstuhl für Diagnostische Radiologie


External institutions with authors

Siemens AG, Healthcare Sector


How to cite

APA:
Grimm, A., Meyer, H., Nickel, M.D., Nittka, M., Raithel, E., Chaudry, O.,... Quick, H.H. (2019). A COMPARISON BETWEEN 6-POINT DIXON MRI AND MR SPECTROSCOPY TO QUANTIFY MUSCLE FAT IN THE THIGH OF SUBJECTS WITH SARCOPENIA. Journal of Frailty & Aging, 8(1), 21-26. https://dx.doi.org/10.14283/jfa.2018.16

MLA:
Grimm, Alexandra, et al. "A COMPARISON BETWEEN 6-POINT DIXON MRI AND MR SPECTROSCOPY TO QUANTIFY MUSCLE FAT IN THE THIGH OF SUBJECTS WITH SARCOPENIA." Journal of Frailty & Aging 8.1 (2019): 21-26.

BibTeX: 

Last updated on 2019-27-05 at 08:33