Hobit- and Blimp-1-driven CD4(+) tissue-resident memory T cells control chronic intestinal inflammation

Journal article


Publication Details

Author(s): Zundler S, Becker E, Spocinska M, Slawik M, Parga-Vidal L, Stark R, Wiendl M, Atreya R, Rath T, Leppkes M, Hildner K, Lopez-Posadas R, Lukassen S, Ekici AB, Neufert C, Atreya I, Van Gisbergen KPJM, Neurath M
Journal: Nature Immunology
Publication year: 2019
Volume: 20
Journal issue: 3
Pages range: 288-+
ISSN: 1529-2908


Abstract

Although tissue-resident memory T cells (T-RM cells) have been shown to regulate host protection in infectious disorders, their function in inflammatory bowel disease (IBD) remains to be investigated. Here we characterized T-RM cells in human IBD and in experimental models of intestinal inflammation. Pro-inflammatory T-RM cells accumulated in the mucosa of patients with IBD, and the presence of CD4(+)CD69(+)CD103(+) T-RM cells was predictive of the development of flares. In vivo, functional impairment of T-RM cells in mice with double knockout of the T-RM-cell-associated transcription factors Hobit and Blimp-1 attenuated disease in several models of colitis, due to impaired cross-talk between the adaptive and innate immune system. Finally, depletion of T-RM cells led to a suppression of colitis activity. Together, our data demonstrate a central role for T-RM cells in the pathogenesis of chronic intestinal inflammation and suggest that these cells could be targets for future therapeutic approaches in IBD.


FAU Authors / FAU Editors

Atreya, Raja Prof. Dr.
Juniorprofessur für chronisch entzündliche Darmerkrankungen
Hildner, Kai Prof. Dr. med.
Juniorprofessur für Pneumologie/ Immunologie
Lopez-Posadas, Rocio Dr.
Medizinische Klinik 1 - Gastroenterologie, Pneumologie und Endokrinologie
Lukassen, Sören
Professur für Humangenetik
Neufert, Clemens PD Dr.
Medizinische Fakultät
Neurath, Markus Prof. Dr.
Lehrstuhl für Innere Medizin I
Rath, Timo Prof. Dr. med.
Medizinische Klinik 1 - Gastroenterologie, Pneumologie und Endokrinologie
Wiendl, Maximilian
Medizinische Klinik 1 - Gastroenterologie, Pneumologie und Endokrinologie
Zundler, Sebastian Dr. med.
Medizinische Klinik 1 - Gastroenterologie, Pneumologie und Endokrinologie


External institutions with authors

University of Amsterdam


How to cite

APA:
Zundler, S., Becker, E., Spocinska, M., Slawik, M., Parga-Vidal, L., Stark, R.,... Neurath, M. (2019). Hobit- and Blimp-1-driven CD4(+) tissue-resident memory T cells control chronic intestinal inflammation. Nature Immunology, 20(3), 288-+. https://dx.doi.org/10.1038/s41590-018-0298-5

MLA:
Zundler, Sebastian, et al. "Hobit- and Blimp-1-driven CD4(+) tissue-resident memory T cells control chronic intestinal inflammation." Nature Immunology 20.3 (2019): 288-+.

BibTeX: 

Last updated on 2019-12-03 at 09:23