Reproducibility of CMRO2 determination using dynamic 17 O MRI
Niesporek SC, Umathum R, Lommen JM, Behl NGR, Paech D, Bachert P, Ladd ME, Nagel AM (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 79
Pages Range: 2923-2934
Journal Issue: 6
DOI: 10.1002/mrm.26952
Abstract
PURPOSE: To assess the reproducibility of 17 O MRI-based determination of the cerebral metabolic rate of oxygen consumption (CMRO2 ) in healthy volunteers. To assess the influence of image acquisition and reconstruction parameters on dynamic quantification of functional parameters such as CMRO2 . METHODS: Dynamic 17 O MRI data were simulated and used to investigate influences of temporal resolution (Δt) and partial volume correction (PVC) on the determination of CMRO2 . Three healthy volunteers were examined in two separate examinations. In vivo 17 O MRI measurements were conducted with a nominal spatial resolution of (7.5 mm)3 using a density-adapted radial sequence with golden angle acquisition scheme. In each measurement, 4.0 ± 0.1 L of 70%-enriched 17 O gas were administered using a rebreathing system. Data were corrected with a PVC algorithm, and CMRO2 was determined in gray matter (GM) and white matter (WM) compartments using a three-phase metabolic model (baseline, 17 O inhalation, decay phase). RESULTS: Comparison with the ground truth of simulations revealed improved CMRO2 determination after application of PVC and with Δt ≤ 2:00 min. Evaluation of in vivo data yields to CMRO2,GM = 2.31 ± 0.1 μmol/g/min and to CMRO2,WM = 0.69 ± 0.04 μmol/g/min with coefficients of variation (CoV) of 0.3-5.5% and 4.3-5.0% for intra-volunteer and inter-volunteer data, respectively. CONCLUSION: This in vivo 17 O inhalation study demonstrated that the proposed experimental setup enables reproducible determination of CMRO2 in healthy volunteers. Magn Reson Med 79:2923-2934, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
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APA:
Niesporek, S.C., Umathum, R., Lommen, J.M., Behl, N.G.R., Paech, D., Bachert, P.,... Nagel, A.M. (2018). Reproducibility of CMRO2 determination using dynamic 17 O MRI. Magnetic Resonance in Medicine, 79(6), 2923-2934. https://dx.doi.org/10.1002/mrm.26952
MLA:
Niesporek, Sebastian C., et al. "Reproducibility of CMRO2 determination using dynamic 17 O MRI." Magnetic Resonance in Medicine 79.6 (2018): 2923-2934.
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