Probing the microscopic environment of 23 Na ions in brain tissue by MRI: On the accuracy of different sampling schemes for the determination of rapid, biexponential T2* decay at low signal-to-noise ratio
Lommen JM, Flassbeck S, Behl NGR, Niesporek S, Bachert P, Ladd ME, Nagel AM (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 80
Pages Range: 571-584
Journal Issue: 2
DOI: 10.1002/mrm.27059
Abstract
PURPOSE: To investigate and to reduce influences on the determination of the short and long apparent transverse relaxation times ( T2,s*, T2,l*) of 23 Na in vivo with respect to signal sampling. METHODS: The accuracy of T2* determination was analyzed in simulations for five different sampling schemes. The influence of noise in the parameter fit was investigated for three different models. A dedicated sampling scheme was developed for brain parenchyma by numerically optimizing the parameter estimation. This scheme was compared in vivo to linear sampling at 7T. RESULTS: For the considered sampling schemes, T2,s* / T2,l* exhibit an average bias of 3% / 4% with a variation of 25% / 15% based on simulations with previously published T2* values. The accuracy could be improved with the optimized sampling scheme by strongly averaging the earliest sample. A fitting model with constant noise floor can increase accuracy while additional fitting of a noise term is only beneficial in case of sampling until late echo time > 80 ms. T2* values in white matter were determined to be T2,s* = 5.1 ± 0.8 / 4.2 ± 0.4 ms and T2,l* = 35.7 ± 2.4 / 34.4 ± 1.5 ms using linear/optimized sampling. CONCLUSION: Voxel-wise T2* determination of 23 Na is feasible in vivo. However, sampling and fitting methods have to be chosen carefully to retrieve accurate results. Magn Reson Med 80:571-584, 2018. © 2018 International Society for Magnetic Resonance in Medicine.
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Germany (DE)How to cite
APA:
Lommen, J.M., Flassbeck, S., Behl, N.G.R., Niesporek, S., Bachert, P., Ladd, M.E., & Nagel, A.M. (2018). Probing the microscopic environment of 23 Na ions in brain tissue by MRI: On the accuracy of different sampling schemes for the determination of rapid, biexponential T2* decay at low signal-to-noise ratio. Magnetic Resonance in Medicine, 80(2), 571-584. https://dx.doi.org/10.1002/mrm.27059
MLA:
Lommen, Jonathan M., et al. "Probing the microscopic environment of 23 Na ions in brain tissue by MRI: On the accuracy of different sampling schemes for the determination of rapid, biexponential T2* decay at low signal-to-noise ratio." Magnetic Resonance in Medicine 80.2 (2018): 571-584.
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