Elevated tissue sodium deposition in patients with type 2 diabetes on hemodialysis detected by 23Na magnetic resonance imaging

Journal article


Publication Details

Author(s): Kopp C, Linz P, Maier C, Wabel P, Hammon M, Nagel AM, Rosenhauer D, Horn S, Uder M, Luft FC, Titze J, Dahlmann A
Journal: Kidney International
Publication year: 2018
Volume: 93
Journal issue: 5
Pages range: 1191-1197
ISSN: 0085-2538


Abstract

Long-term elevated blood sugar levels result in tissue matrix compositional changes in patients with diabetes mellitus type 2 (T2DM). We hypothesized that hemodialysis patients with T2DM might accumulate more tissue sodium than control hemodialysis patients. To test this, 23Na magnetic resonance imaging (23Na MRI) was used to estimate sodium in skin and muscle tissue in hemodialysis patients with or without T2DM. Muscle fat content was estimated by 1H MRI and tissue sodium content by 23Na MRI pre- and post-hemodialysis in ten hemodialysis patients with T2DM and in 30 matched control hemodialysis patients. We also assessed body fluid distribution with the Body Composition Monitor. 1H MRI indicated a tendency to higher muscle fat content in hemodialysis patients with T2DM compared to non-diabetic hemodialysis patients. 23Na MRI indicated increased sodium content in muscle and skin tissue of hemodialysis patients with T2DM compared to control hemodialysis patients. Multi-frequency bioimpedance was used to estimate extracellular water (ECW), and excess ECW in T2DM hemodialysis patients correlated with HbA1c levels. Sodium mobilization during hemodialysis lowered muscle sodium content post-dialysis to a greater degree in T2DM hemodialysis patients than in control hemodialysis patients. Thus, our findings provide evidence that increased sodium accumulation occurs in hemodialysis patients with T2DM and that impaired serum glucose metabolism is associated with disturbances in tissue sodium and water content.


FAU Authors / FAU Editors

Hammon, Matthias PD Dr.
Radiologisches Institut
Linz, Peter Dr. rer. nat.
Radiologisches Institut
Maier, Carolin
Professur für Innere Medizin (Hochdruckforschung)
Nagel, Armin Michael Prof. Dr.
Professur für metabolische und funktionelle MR-Bildgebung
Titze, Jens Prof. Dr.
Medizinische Klinik 4 - Nephrologie und Hypertensiologie
Uder, Michael Prof. Dr.
Lehrstuhl für Diagnostische Radiologie


External institutions with authors

Experimental and Clinical Research Center (ECRC)
Fresenius Medical Care Deutschland GmbH


How to cite

APA:
Kopp, C., Linz, P., Maier, C., Wabel, P., Hammon, M., Nagel, A.M.,... Dahlmann, A. (2018). Elevated tissue sodium deposition in patients with type 2 diabetes on hemodialysis detected by 23Na magnetic resonance imaging. Kidney International, 93(5), 1191-1197. https://dx.doi.org/10.1016/j.kint.2017.11.021

MLA:
Kopp, Christoph, et al. "Elevated tissue sodium deposition in patients with type 2 diabetes on hemodialysis detected by 23Na magnetic resonance imaging." Kidney International 93.5 (2018): 1191-1197.

BibTeX: 

Last updated on 2019-11-03 at 12:08