Elevated tissue sodium deposition in patients with type 2 diabetes on hemodialysis detected by 23Na magnetic resonance imaging

Kopp C, Linz P, Maier C, Wabel P, Hammon M, Nagel AM, Rosenhauer D, Horn S, Uder M, Luft FC, Titze J, Dahlmann A (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Kidney International Nature Publishing Group: Open Access Hybrid Model Option A

Book Volume: 93

Pages Range: 1191-1197

Journal Issue: 5

DOI: 10.1016/j.kint.2017.11.021

Abstract

Long-term elevated blood sugar levels result in tissue matrix compositional changes in patients with diabetes mellitus type 2 (T2DM). We hypothesized that hemodialysis patients with T2DM might accumulate more tissue sodium than control hemodialysis patients. To test this, 23Na magnetic resonance imaging (23Na MRI) was used to estimate sodium in skin and muscle tissue in hemodialysis patients with or without T2DM. Muscle fat content was estimated by 1H MRI and tissue sodium content by 23Na MRI pre- and post-hemodialysis in ten hemodialysis patients with T2DM and in 30 matched control hemodialysis patients. We also assessed body fluid distribution with the Body Composition Monitor. 1H MRI indicated a tendency to higher muscle fat content in hemodialysis patients with T2DM compared to non-diabetic hemodialysis patients. 23Na MRI indicated increased sodium content in muscle and skin tissue of hemodialysis patients with T2DM compared to control hemodialysis patients. Multi-frequency bioimpedance was used to estimate extracellular water (ECW), and excess ECW in T2DM hemodialysis patients correlated with HbA1c levels. Sodium mobilization during hemodialysis lowered muscle sodium content post-dialysis to a greater degree in T2DM hemodialysis patients than in control hemodialysis patients. Thus, our findings provide evidence that increased sodium accumulation occurs in hemodialysis patients with T2DM and that impaired serum glucose metabolism is associated with disturbances in tissue sodium and water content.

Authors with CRIS profile

Peter Linz Institute of Radiology Carolin Maier Professur für Innere Medizin (Hochdruckforschung) Matthias Hammon Institute of Radiology Armin Michael Nagel Professur für metabolische und funktionelle MR-Bildgebung Michael Uder Lehrstuhl für Diagnostische Radiologie Jens Titze Department of Medicine 4 – Nephrology and Hypertension Anke Dahlmann Department of Medicine 4 – Nephrology and Hypertension

Involved external institutions

Experimental and Clinical Research Center (ECRC) DE Germany (DE) Fresenius Medical Care Deutschland GmbH DE Germany (DE)

How to cite

APA:

Kopp, C., Linz, P., Maier, C., Wabel, P., Hammon, M., Nagel, A.M.,... Dahlmann, A. (2018). Elevated tissue sodium deposition in patients with type 2 diabetes on hemodialysis detected by 23Na magnetic resonance imaging. Kidney International, 93(5), 1191-1197. https://dx.doi.org/10.1016/j.kint.2017.11.021

MLA:

Kopp, Christoph, et al. "Elevated tissue sodium deposition in patients with type 2 diabetes on hemodialysis detected by 23Na magnetic resonance imaging." Kidney International 93.5 (2018): 1191-1197.

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