Brief Report: Association of Quantitative and Topographic Assessment of Heberden's Nodes With Knee Osteoarthritis: Data From the Osteoarthritis Initiative

Journal article
(Report)


Publication Details

Author(s): Kumar NM, Hafezi-Nejad N, Guermazi A, Haj-Mirzaian A, Haugen IK, Roemer F, Demehri S
Journal: Arthritis and Rheumatology
Publication year: 2018
Volume: 70
Journal issue: 8
Pages range: 1234-1239
ISSN: 2326-5191
eISSN: 2326-5205


Abstract

OBJECTIVE: To determine whether the presence, number, and topography (digit location and symmetry) of Heberden's nodes are associated with the incidence and progression of radiographic osteoarthritis (OA) of the knee.
METHODS: We analyzed 8,023 knees (with 8 years of follow-up) from the Osteoarthritis Initiative. Cox regression was performed on Heberden's node presence, total number, location, and symmetry (using 2 symmetry index models) obtained at baseline physical examination as well as self-report of Heberden's node presence for evaluation of association with radiographic knee OA incidence (development of a Kellgren/Lawrence grade of ≥2) and progression (worsening in the medial joint space narrowing score of ≥1). Covariate adjustments relevant to OA outcomes were performed.
RESULTS: The presence of Heberden's nodes (in 64% of the subjects) at baseline physical examinations, but not subjective self-report of Heberden's nodes, was associated with radiographic knee OA incidence (hazard ratio [HR] 1.19 and 95% confidence interval [95% CI] 1.001-1.402 [approached statistical significance]). Each additional Heberden's node found on physical examination was associated with knee OA incidence (HR 1.03 [95% CI 1.000-1.054] [approached statistical significance]) and progression (HR 1.04 [95% CI 1.016-1.063]). Knee OA incidence and progression were associated with Heberden's nodes located on the third digit (HR 1.26 [95% CI 1.068-1.487] and 1.18 [95% CI 1.019-1.361], respectively) and first digit (HR 1.186 [95% CI 0.992-1.418] [approached statistical significance] and HR 1.26 [95% CI 1.084-1.453], respectively). Heberden's node symmetry was associated with knee OA incidence (model 1 HR 1.09 [95% CI 0.997-1.185] [approached statistical significance]) and progression (model 2 HR 1.13 [95% CI 1.035-1.234]).
CONCLUSION: The number of Heberden's nodes, their locations, and symmetry were associated with knee OA incidence and progression over 8 years.


FAU Authors / FAU Editors

Roemer, Frank Prof. Dr.
Radiologisches Institut


External institutions with authors

Boston University
Diakonhjemmet Hospital
Johns Hopkins University
University of Maryland, Baltimore County


How to cite

APA:
Kumar, N.M., Hafezi-Nejad, N., Guermazi, A., Haj-Mirzaian, A., Haugen, I.K., Roemer, F., & Demehri, S. (2018). Brief Report: Association of Quantitative and Topographic Assessment of Heberden's Nodes With Knee Osteoarthritis: Data From the Osteoarthritis Initiative. Arthritis and Rheumatology, 70(8), 1234-1239. https://dx.doi.org/10.1002/art.40463

MLA:
Kumar, Neil M., et al. "Brief Report: Association of Quantitative and Topographic Assessment of Heberden's Nodes With Knee Osteoarthritis: Data From the Osteoarthritis Initiative." Arthritis and Rheumatology 70.8 (2018): 1234-1239.

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Last updated on 2019-06-03 at 10:08