Double quantum filtered 23 Na MRI with magic angle excitation of human skeletal muscle in the presence of B0 and B1 inhomogeneities

Journal article


Publication Details

Author(s): Gast L, Gerhalter T, Hensel B, Uder M, Nagel AM
Journal: NMR in Biomedicine
Publication year: 2018
Volume: 31
Journal issue: 12
ISSN: 0952-3480
eISSN: 1099-1492


Abstract

Double quantum filtered 23 Na MRI with magic angle excitation (DQF-MA) can be used to selectively detect sodium ions located within anisotropic structures such as muscle fibers. It might therefore be a promising tool to analyze the microscopic environment of sodium ions, for example in the context of osmotically neutral sodium retention. However, DQF-MA imaging is challenging due to various signal dependences, on both measurement parameters and external influences. The aim of this work was to examine how B0 in combination with B1 inhomogeneities alter the DQF-MA signal intensity. We showed that, in the presence of B0 inhomogeneities, flip angle schemes with only one 54.7° pulse can be favorable compared with the classical 90°-54.7°-54.7° scheme. DQF-MA images of the human lower leg were acquired at B0  = 3 T with a nominal spatial resolution of 12 × 12 × 36 mm3 within an acquisition time of TAcq  < 10 min, and compared with spin density weighted (DW), as well as triple quantum filtration (TQF) 23 Na images. We found mean normalized signal-to-noise ratios of TQF/DW = 13.7 ± 2.3% (tibialis anterior), 11.9 ± 2.3% (soleus) and 11.4 ± 2.2% (gastrocnemius medialis), as well as DQF-MA/DW = 4.7 ± 1.1% (tibialis anterior), 3.3 ± 0.73% (soleus) and 3.4 ± 0.6% (gastrocnemius medialis). These ratios might serve as additional measures in future clinical studies of sodium retention within human skeletal muscle. However, the influence of B0 and B1 inhomogeneities should be considered when interpreting DQF-MA images.


FAU Authors / FAU Editors

Gast, Lena
Radiologisches Institut
Hensel, Bernhard Prof. Dr.
Max Schaldach-Stiftungsprofessur für Biomedizinische Technik
Nagel, Armin Michael Prof. Dr.
Professur für metabolische und funktionelle MR-Bildgebung
Uder, Michael Prof. Dr.
Lehrstuhl für Diagnostische Radiologie


Additional Organisation
Zentrum für Medizinische Physik und Technik


How to cite

APA:
Gast, L., Gerhalter, T., Hensel, B., Uder, M., & Nagel, A.M. (2018). Double quantum filtered 23 Na MRI with magic angle excitation of human skeletal muscle in the presence of B0 and B1 inhomogeneities. NMR in Biomedicine, 31(12). https://dx.doi.org/10.1002/nbm.4010

MLA:
Gast, Lena, et al. "Double quantum filtered 23 Na MRI with magic angle excitation of human skeletal muscle in the presence of B0 and B1 inhomogeneities." NMR in Biomedicine 31.12 (2018).

BibTeX: 

Last updated on 2019-19-08 at 13:23