A randomized controlled trial of the effect of spironolactone on left ventricular mass in hemodialysis patients

Hammer F, Malzahn U, Donhauser J, Betz C, Schneider M, Grupp C, Pollak N, Störk S, Wanner C, Krane V, Berweck S, Biggar P, Blaser C, Bochannek T, Breunig F, Brunner M, Büschges-Seraphin B, Büttner S, Cakmak A, Döltz T, Dörken M, Eckardt KU, Fink H, Fischer S, Freisinger W, Freiwald T, Gebhardt J, Geiger H, Götz R, Goßmann J, Hammerstingl R, Harazny J, Heckel M, Heyd-Schramm A, Hoyer J, Janka R, Jung O, Ketteler M, Klaeffling C, Kleinert C, Kleinert M, Klingbeil A, Klink T, Koch BF, Kosowski J, Leidig M, Lutz J, Moritz M, Moye B, Naujoks H, Netzer KO, Raff U, Reichert C, Reimer I, Ribel J, Richter S, Ritter C, Rudolf S, Schamberger B, Schmid M, Schmiedeke T, Schmitt A, Schneider H, Schneider R, Schneuzer C, Schöffauer M, Schramm L, Schütterle S, Schwedler S, Sobkowiak E, Sollinger D, Strutz F, Toncar S, Vasiljuk V, Vogl T, Walther T, Weinmann-Menke J, Wirth B, Witsch H, Würmell P, Zeltner R, Zimmermann J, Marwan M (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Kidney International Nature Publishing Group: Open Access Hybrid Model Option A

DOI: 10.1016/j.kint.2018.11.025

Abstract

Mineralocorticoid receptor antagonists have beneficial effects on left ventricular remodeling, cardiac fibrosis, and arrhythmia in heart failure, but efficacy and safety in dialysis patients is less clear. We evaluated the effect of spironolactone on left ventricular mass (LVM), an independent predictor of all-cause and cardiovascular mortality, in hemodialysis patients. In this placebo-controlled, parallel-group trial, 97 hemodialysis patients (23% female; mean age 60.3 years) were randomized to spironolactone 50 mg once daily (n=50) or placebo (n=47). The primary efficacy endpoint was change in LVM index (LVMi) from baseline to 40 weeks as determined by cardiac magnetic resonance imaging. Safety endpoints were development of hyperkalemia and change in residual renal function. There was no significant change in LVMi in participants randomized to spironolactone compared to placebo (-2.86±11.87 vs. 0.41±10.84 g/m2). There was also no difference in the secondary outcomes of mean 24-hour systolic or diastolic ambulatory blood pressure, left ventricular ejection fraction, 6-minute walk test distance, or New York Heart Association functional class. Moderate hyperkalemia (pre-dialysis potassium levels of 6.0-6.5 mmol/L) was more frequent with spironolactone treatment (155 vs. 80 events), but severe hyperkalemia (≥6.5 mmol/L) was not (14 vs. 24 events). Changes in residual urine volume and measured glomerular filtration rate did not differ between groups. There were no deaths in the spironolactone group and 4 deaths in the placebo group. Thus, treatment with 50 mg spironolactone did not change left ventricular mass index, cardiac function, or blood pressure in hemodialysis patients. Spironolactone increased the frequency of moderate hyperkalemia, but did not increase severe hyperkalemia.

Authors with CRIS profile

Markus Schneider Medizinische Fakultät Mohamed Marwan Department of Medicine 2 – Cardiology and Angiology

Involved external institutions

Universitätsklinikum Würzburg DE Germany (DE) Universitätsklinikum Frankfurt am Main (KGU) DE Germany (DE) Julius-Maximilians-Universität Würzburg DE Germany (DE)

How to cite

APA:

Hammer, F., Malzahn, U., Donhauser, J., Betz, C., Schneider, M., Grupp, C.,... Marwan, M. (2019). A randomized controlled trial of the effect of spironolactone on left ventricular mass in hemodialysis patients. Kidney International. https://dx.doi.org/10.1016/j.kint.2018.11.025

MLA:

Hammer, Fabian, et al. "A randomized controlled trial of the effect of spironolactone on left ventricular mass in hemodialysis patients." Kidney International (2019).

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