The "Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies" (SPRINTT) randomized controlled trial: Case finding, screening and characteristics of eligible participants

Marzetti E, Cesari M, Calvani R, Msihid J, Tosato M, Rodriguez-Manas L, Lattanzio F, Cherubini A, Bejuit R, Bari MD, Maggio M, Vellas B, Dantoine T, Cruz-Jentoft AJ, Sieber C, Freiberger E, Skalska A, Grodzicki T, Sinclair AJ, Topinkova E, Ryznarova I, Strandberg T, Schols AMWJ, Schols JMGA, Roller-Wirnsberger R, Jonsson P, Ramel A, Del Signore S, Pahor M, Roubenoff R, Bernabei R, Landi F (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Book Volume: 113

Pages Range: 48-57

DOI: 10.1016/j.exger.2018.09.017

Abstract

Background: The ongoing "Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies (SPRINTT)"randomized controlled trial (RCT) is testing the efficacy of a multicomponent intervention in the prevention of mobility disability in older adults with physical frailty & sarcopenia (PF& S). Here, we describe the procedures followed for PF& S case finding and screening of candidate participants for the SPRINTT RCT. We also illustrate the main demographic and clinical characteristics of eligible screenees. Methods: The identification of PF& S was based on the co-occurrence of three defining elements: (1) reduced physical performance (defined as a score on the Short Physical Performance Battery between 3 and 9); (2) low muscle mass according to the criteria released by the Foundation for the National Institutes of Health; and (3) absence of mobility disability (defined as ability to complete the 400-m walk test in 15 min). SPRINTT was advertised through a variety of means. Site-specific case finding strategies were developed to accommodate the variability across centers in catchment area characteristics and access to the target population. A quick "participant profiling"questionnaire was devised to facilitate PF& S case finding. Results: During approximately 22 months, 12,358 prescreening interviews were completed in 17 SPRINTT sites resulting in 6710 clinic screening visits. Eventually, 1566 candidates were found to be eligible for participating in the SPRINTT RCT. Eligible screenees showed substantial physical function impairment and comorbidity burden. In most centers, project advertisement through mass media was the most rewarding case finding strategy. Conclusion: PF& S case finding in the community is a challenging, but feasible task. Although largely autonomous in daily life activities, older adults with PF& S suffer from significant functional impairment and comorbidity. This subset of the older population is therefore at high risk for disability and other negative health-related events. Key strategies to consider for successfully intercepting at-risk older adults should focus on mass communication methods.

Authors with CRIS profile

Involved external institutions

Diabetes Frail at Medici Medical Centre United Kingdom (GB) Azienda Ospedaliero-Universitaria di Parma / Parma University Hospital Italy (IT) The Silesian Hospital in Opava Czech Republic (CZ) Maastricht University Netherlands (NL) University of Iceland (UI) / Háskóli Íslands Iceland (IS) Catholic University of the Sacred Heart / Università Cattolica del Sacro Cuore Italy (IT) Istituto Nazionale di Riposo e Cura per Anziani (IRCCS INRCA) Italy (IT) Hospital Center University De Limoges Dupuytren France (FR) Hospital Universitario Ramón y Cajal Spain (ES) Blue Companion Ltd. United Kingdom (GB) Jagiellonian University / Uniwersytet Jagielloński (UJ) Poland (PL) Sanofi-Aventis Groupe France (FR) Centre Hospitalier Universitaire (CHU) de Toulouse France (FR) Helsingin yliopisto / University of Helsinki Finland (FI) Università degli studi di Milano Italy (IT) Novartis AG Switzerland (CH) Univerzita Karlova v Praze / Charles University in Prague Czech Republic (CZ) Università degli Studi di Firenze / University of Florence Italy (IT) Hospital Universitario de Getafe Spain (ES) University of Florida United States (USA) (US)

How to cite

APA:

Marzetti, E., Cesari, M., Calvani, R., Msihid, J., Tosato, M., Rodriguez-Manas, L.,... Landi, F. (2018). The "Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies" (SPRINTT) randomized controlled trial: Case finding, screening and characteristics of eligible participants. Experimental Gerontology, 113, 48-57. https://dx.doi.org/10.1016/j.exger.2018.09.017

MLA:

Marzetti, Emanuele, et al. "The "Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies" (SPRINTT) randomized controlled trial: Case finding, screening and characteristics of eligible participants." Experimental Gerontology 113 (2018): 48-57.

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