Prognostic value of age adjusted segment involvement score as measured by coronary computed tomography: a potential marker of vascular age

Journal article


Publication Details

Author(s): Ayoub C, Kritharides L, Yam Y, Chen L, Hossain A, Achenbach S, Al-Mallah MH, Andreini D, Berman DS, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Chinnaiyan K, Cury RC, Delago A, Dunning A, Feuchtner G, Gomez M, Gransar H, Hadamitzky M, Hausleiter J, Hindoyan N, Kaufmann PA, Kim YJ, Leipsic J, Maffei E, Marques H, Pontone G, Raff G, Rubinshtein R, Shaw LJ, Villines TC, Min JK, Chow BJW
Journal: Heart and Vessels
Publication year: 2018
Volume: 33
Journal issue: 11
Pages range: 1288-1300
ISSN: 0910-8327


Abstract

Extent of coronary atherosclerotic disease (CAD) burden on coronary computed tomography angiography (CCTA) as measured by segment involvement score (SIS) has a prognostic value. We sought to investigate the incremental prognostic value of 'age adjusted SIS' (aSIS), which may be a marker of premature atherosclerosis and vascular age. Consecutive patients were prospectively enrolled into the CONFIRM (Coronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicentre) multinational observational study. Patients were followed for the outcome of all-cause death. aSIS was calculated on CCTA for each patient, and its incremental prognostic value was evaluated. A total of 22,211 patients [mean age 58.5 ± 12.7 years, 55.8% male) with a median follow-up of 27.3 months (IQR 17.8, 35.4)] were identified. After adjustment for clinical factors and presence of obstructive CAD, higher aSIS was associated with increased death on multivariable analysis, with hazard ratio (HR) 2.40 (1.83-3.16, p < 0.001), C-statistic 0.723 (0.700-0.756), net reclassification improvement (NRI) 0.36 (0.26-0.47, p < 0.001), and relative integrated discrimination improvement (IDI) 0.33 (p = 0.009). aSIS had HR 3.48 (2.33-5.18, p < 0.001) for mortality in those without obstructive CAD, compared to HR 1.79 (1.25-2.58, p = 0.02) in those with obstructive CAD. In conclusion, aSIS has an incremental prognostic value to traditional risk factors and obstructive CAD, and may enhance CCTA risk stratification.


FAU Authors / FAU Editors

Achenbach, Stephan Prof. Dr. med.
Lehrstuhl für Innere Medizin II


External institutions with authors

Baptist Health South Florida
Beaumont Health System
Capitol Cardiology Associates
Casa di Cura Giovanni XXIII
Cedars-Sinai Medical Center
Cornell University
Deutsches Herzzentrum München
Duke University Medical Center
Emory University
Harbor–UCLA Medical Center
Hospital Curry Cabral
King Abdulaziz Cardiac Center
Medizinische Universität Innsbruck
Seoul National University (SNU) / 서울대학교
Technion - Israel Institute of Technology
Tennessee Heart & Vascular
Università degli studi di Milano
Universitätsspital Zürich (USZ)
University of British Columbia
University of Ottawa
University of Sydney
Walter Reed Army Medical Center (WRAMC)
Yonsei University


How to cite

APA:
Ayoub, C., Kritharides, L., Yam, Y., Chen, L., Hossain, A., Achenbach, S.,... Chow, B.J.W. (2018). Prognostic value of age adjusted segment involvement score as measured by coronary computed tomography: a potential marker of vascular age. Heart and Vessels, 33(11), 1288-1300. https://dx.doi.org/10.1007/s00380-018-1188-3

MLA:
Ayoub, Chadi, et al. "Prognostic value of age adjusted segment involvement score as measured by coronary computed tomography: a potential marker of vascular age." Heart and Vessels 33.11 (2018): 1288-1300.

BibTeX: 

Last updated on 2019-01-03 at 08:23