Association of CamK2A genetic variants with transition time from occasional to regular heroin use in a sample of heroin-dependent individuals

Journal article


Publication Details

Author(s): Eirich A, Biermann T, Müller CP, Kornhuber J, Benyamin B, Hulse GK, Wildenauer DB, Schwab S
Journal: Psychiatric Genetics
Publication year: 2019
Volume: 29
Journal issue: 1
Pages range: 18-25
ISSN: 0955-8829


Abstract

Objectives Susceptibility to heroin dependence is strongly influenced by genetic factors with heritability estimates as high as 0.7. A number of genes, as well as environmental factors, are likely to contribute to its etiology. Not all individuals who have ever tried heroin at some stage during their lifetime become dependent on heroin. It has been suggested that genetic factors might be more important in the transition stage to heroin dependence rather than in environmental exposures and experimenting with heroin. As the features of substance dependence and memory formation have been found to be strikingly similar, we have focused on a key enzyme involved in long-term potentiation and synaptic plasticity, namely the calcium-dependent/calmodulin-dependent protein kinase IIa (CAMKIIa). We hypothesized, that CamK2A genetic variation may play a role in the transition from occasional to regular heroin use.


FAU Authors / FAU Editors

Eirich, Antonia
Professur für Molekulare Psychiatrie
Kornhuber, Johannes Prof. Dr. med.
Lehrstuhl für Psychiatrie und Psychotherapie
Müller, Christian P. Prof. Dr.
Professur für Suchtmedizin
Schwab, Sibylle Prof. Dr.
Professur für Molekulare Psychiatrie


External institutions with authors

University of South Australia
University of Western Australia (UWA)


How to cite

APA:
Eirich, A., Biermann, T., Müller, C.P., Kornhuber, J., Benyamin, B., Hulse, G.K.,... Schwab, S. (2019). Association of CamK2A genetic variants with transition time from occasional to regular heroin use in a sample of heroin-dependent individuals. Psychiatric Genetics, 29(1), 18-25. https://dx.doi.org/10.1097/YPG.0000000000000208

MLA:
Eirich, Antonia, et al. "Association of CamK2A genetic variants with transition time from occasional to regular heroin use in a sample of heroin-dependent individuals." Psychiatric Genetics 29.1 (2019): 18-25.

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Last updated on 2019-01-03 at 08:38