Association of CamK2A genetic variants with transition time from occasional to regular heroin use in a sample of heroin-dependent individuals

Eirich A, Biermann T, Müller CP, Kornhuber J, Benyamin B, Hulse GK, Wildenauer DB, Schwab S (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Psychiatric Genetics Lippincott, Williams & Wilkins

Book Volume: 29

Pages Range: 18-25

Journal Issue: 1

DOI: 10.1097/YPG.0000000000000208

Abstract

Objectives Susceptibility to heroin dependence is strongly influenced by genetic factors with heritability estimates as high as 0.7. A number of genes, as well as environmental factors, are likely to contribute to its etiology. Not all individuals who have ever tried heroin at some stage during their lifetime become dependent on heroin. It has been suggested that genetic factors might be more important in the transition stage to heroin dependence rather than in environmental exposures and experimenting with heroin. As the features of substance dependence and memory formation have been found to be strikingly similar, we have focused on a key enzyme involved in long-term potentiation and synaptic plasticity, namely the calcium-dependent/calmodulin-dependent protein kinase IIa (CAMKIIa). We hypothesized, that CamK2A genetic variation may play a role in the transition from occasional to regular heroin use.

Authors with CRIS profile

Antonia Eirich Professur für Molekulare Psychiatrie Peter Christian Müller Professur für Suchtmedizin Johannes Kornhuber Lehrstuhl für Psychiatrie und Psychotherapie Sibylle Schwab Professur für Molekulare Psychiatrie

Involved external institutions

University of Western Australia (UWA) AU Australia (AU) University of South Australia AU Australia (AU)

How to cite

APA:

Eirich, A., Biermann, T., Müller, C.P., Kornhuber, J., Benyamin, B., Hulse, G.K.,... Schwab, S. (2019). Association of CamK2A genetic variants with transition time from occasional to regular heroin use in a sample of heroin-dependent individuals. Psychiatric Genetics, 29(1), 18-25. https://dx.doi.org/10.1097/YPG.0000000000000208

MLA:

Eirich, Antonia, et al. "Association of CamK2A genetic variants with transition time from occasional to regular heroin use in a sample of heroin-dependent individuals." Psychiatric Genetics 29.1 (2019): 18-25.

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