Lipid Peroxidation Drives Renal Cyst Growth In Vitro through Activation of TMEM16A

Journal article


Publication Details

Author(s): Schreiber R, Buchholz B, Kraus A, Schley G, Scholz J, Ousingsawat J, Kunzelmann K
Journal: Journal of the American Society of Nephrology
Publication year: 2019
Volume: 30
Journal issue: 2
Pages range: 228-242
ISSN: 1046-6673
eISSN: 1533-3450


Abstract

Background Transepithelial chloride2 secretion, through the chloride channels cystic fibrosis transmembrane conductance regulator (CFTR) and TMEM16A (anoctamin 1), drives cyst enlargement in polycystic kidney disease (PKD). Polycystic kidneys are hypoxic, and oxidative stress activates TMEM16A. However, mechanisms for channel activation in PKD remain obscure.


FAU Authors / FAU Editors

Kraus, Andre Dr. rer. nat.
Medizinische Klinik 4 - Nephrologie und Hypertensiologie


External institutions with authors

Universität Regensburg


How to cite

APA:
Schreiber, R., Buchholz, B., Kraus, A., Schley, G., Scholz, J., Ousingsawat, J., & Kunzelmann, K. (2019). Lipid Peroxidation Drives Renal Cyst Growth In Vitro through Activation of TMEM16A. Journal of the American Society of Nephrology, 30(2), 228-242. https://dx.doi.org/10.1681/ASN.2018010039

MLA:
Schreiber, Rainer, et al. "Lipid Peroxidation Drives Renal Cyst Growth In Vitro through Activation of TMEM16A." Journal of the American Society of Nephrology 30.2 (2019): 228-242.

BibTeX: 

Last updated on 2019-26-07 at 09:19