Functionalized Superparamagnetic Iron Oxide Nanoparticles (SPIONs) as Platform for the Targeted Multimodal Tumor Therapy

Journal article


Publication Details

Author(s): Janko C, Ratschker T, Nguyen K, Zschiesche L, Tietze R, Lyer S, Alexiou C
Journal: Frontiers in Oncology
Publication year: 2019
Volume: 9
Pages range: 59
ISSN: 2234-943X


Abstract

Standard cancer treatments involve surgery, radiotherapy, chemotherapy, and immunotherapy. In clinical practice, the respective drugs are applied orally or intravenously leading to their systemic circulation in the whole organism. For chemotherapeutics or immune modulatory agents, severe side effects such as immune depression or autoimmunity can occur. At the same time the intratumoral drug doses are often too low for effective cancer therapy. Since monotherapies frequently cannot cure cancer, due to their synergistic effects multimodal therapy concepts are applied to enhance treatment efficacy. The targeted delivery of drugs to the tumor by employment of functionalized nanoparticles might be a promising solution to overcome these challenges. For multimodal therapy concepts and individualized patient care nanoparticle platforms can be functionalized with compounds from various therapeutic classes (e.g. radiosensitizers, phototoxic drugs, chemotherapeutics, immune modulators). Superparamagnetic iron oxide nanoparticles (SPIONs) as drug transporters can add further functionalities, such as guidance or heating by external magnetic fields (Magnetic Drug Targeting or Magnetic Hyperthermia), and imaging-controlled therapy (Magnetic Resonance Imaging).


FAU Authors / FAU Editors

Alexiou, Christoph Prof. Dr.
Professur für Nanomedizin
Janko, Christina Dr. rer. nat.
Hals-Nasen-Ohren-Klinik - Kopf- und Halschirurgie
Lyer, Stefan Dr. rer. nat.
Hals-Nasen-Ohren-Klinik - Kopf- und Halschirurgie
Tietze, Rainer Dr. rer. nat.
Hals-Nasen-Ohren-Klinik - Kopf- und Halschirurgie


How to cite

APA:
Janko, C., Ratschker, T., Nguyen, K., Zschiesche, L., Tietze, R., Lyer, S., & Alexiou, C. (2019). Functionalized Superparamagnetic Iron Oxide Nanoparticles (SPIONs) as Platform for the Targeted Multimodal Tumor Therapy. Frontiers in Oncology, 9, 59. https://dx.doi.org/10.3389/fonc.2019.00059

MLA:
Janko, Christina, et al. "Functionalized Superparamagnetic Iron Oxide Nanoparticles (SPIONs) as Platform for the Targeted Multimodal Tumor Therapy." Frontiers in Oncology 9 (2019): 59.

BibTeX: 

Last updated on 2019-11-07 at 08:50