Low incidence of symptomatic osteonecrosis after allogeneic HSCT in children with high-risk or relapsed ALL - results of the ALL-SCT 2003 trial

Kuhlen M, Bader P, Sauer M, Albert MH, Gruhn B, Gungor T, Kropshofer G, Lang P, Lawitschka A, Metzler M, Pentek F, Rossig C, Schlegel PG, Schrappe M, Schrum J, Schulz A, Schwinger W, Von Stackelberg A, Strahm B, Suttorp M, Teichert-Von Luettichau I, Woessmann W, Borkhardt A, Meisel R, Poetschger U, Glogova E, Peters C (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Book Volume: 183

Pages Range: 104-109

Journal Issue: 1

DOI: 10.1111/bjh.15511

Abstract

Osteonecrosis (ON) was prospectively assessed in 557 children and adolescents in the Berlin-Frankfurt-Münster Stem Cell Transplantation in children with acute lymphoblastic leukaemia 2003 trial. Median age at haematopoietic stem cell transplantation (HSCT) was 10·3 years (range 0·5-26). Cumulative incidence of symptomatic ON (sON) was 9% at 5 years (standard deviation 1%), median time from HSCT to diagnosis of sON was 12·4 months (range 1-126). Multivariate analysis identified age at HSCT [10-15 years vs. <10 years: hazard ratio (HR) 3·73, P = 0·009; >15 years vs. <10 years: HR 5·46, P = 0·001], diagnosis of sON prior to HSCT and chronic graft-versus-host disease (yes versus no: HR 2·696, P = 0·015) as significant independent risk factors for the development of sON.

Authors with CRIS profile

Involved external institutions

Universitäts-Kinderspital Zürich Switzerland (CH) Heinrich-Heine-Universität Düsseldorf Germany (DE) Universitätsklinikum Frankfurt am Main (KGU) Germany (DE) Medizinische Hochschule Hannover (MHH) / Hannover Medical School Germany (DE) Ludwig-Maximilians-Universität (LMU) Germany (DE) Universitätsklinikum Jena Germany (DE) Medizinische Universität Innsbruck Austria (AT) Universitätsklinikum Tübingen Germany (DE) Medizinische Universität Wien Austria (AT) Universitätsklinikum Essen Germany (DE) Universitätsklinikum Münster Germany (DE) Julius-Maximilians-Universität Würzburg Germany (DE) Universitätsklinikum Schleswig-Holstein (UKSH) Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) Germany (DE) Universitätsklinikum Heidelberg Germany (DE) Charité - Universitätsmedizin Berlin Germany (DE) Albert-Ludwigs-Universität Freiburg Germany (DE) Technische Universität Dresden Germany (DE) Technische Universität München (TUM) Germany (DE) Justus-Liebig-Universität Gießen Germany (DE)

How to cite

APA:

Kuhlen, M., Bader, P., Sauer, M., Albert, M.H., Gruhn, B., Gungor, T.,... Peters, C. (2018). Low incidence of symptomatic osteonecrosis after allogeneic HSCT in children with high-risk or relapsed ALL - results of the ALL-SCT 2003 trial. British Journal of Haematology, 183(1), 104-109. https://dx.doi.org/10.1111/bjh.15511

MLA:

Kuhlen, Michaela, et al. "Low incidence of symptomatic osteonecrosis after allogeneic HSCT in children with high-risk or relapsed ALL - results of the ALL-SCT 2003 trial." British Journal of Haematology 183.1 (2018): 104-109.

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