Local recurrence of breast cancer: conventionally fractionated partial external beam re-irradiation with curative intention
Janssen S, Rades D, Meyer A, Fahlbusch FB, Wildfang I, Meier A, Schild S, Christiansen H, Henkenberens C (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 194
Pages Range: 806-814
Journal Issue: 9
DOI: 10.1007/s00066-018-1315-1
Abstract
PURPOSE: To assess the outcome of breast cancer patients with local recurrence who underwent partial external beam re-irradiation (re-RT) either as part of a second breast-conserving therapy or following mastectomy. METHODS: Between 03/2004 and 10/2016, 83 breast cancer patients with local recurrence were treated with surgery followed by re-RT. The re-RT schedules were 45 Gy (1.8 Gy per fraction) administered either to the partial breast (n = 42) or mastectomy scar (n = 41). The patients and tumor characteristics predictive of local control, distant control, and survival (overall and breast-cancer specific) were evaluated by univariate and multivariate analyses. RESULTS: The median follow-up was 35 months (range 3-143 months). The median time interval between the first irradiation and re-RT was 117 months (range 16-357 months). The prognostic factors for favorable overall survival rates were younger age (p = 0.045), lower T‑category (p = 0.019), and N0 category (p = 0.005). N0 was also superior to N+ with respect to outfield recurrences (p = <0.001) and breast cancer-specific survival (p = 0.025). Acute and late skin toxicity was generally low (
Involved external institutions
Universität zu Lübeck
Germany (DE)
Medizinische Hochschule Hannover (MHH) / Hannover Medical School
Germany (DE)
Mayo Clinic
United States (USA) (US)
Germany (DE)
Medizinische Hochschule Hannover (MHH) / Hannover Medical School
Germany (DE)
Mayo Clinic
United States (USA) (US)
How to cite
APA:
Janssen, S., Rades, D., Meyer, A., Fahlbusch, F.B., Wildfang, I., Meier, A.,... Henkenberens, C. (2018). Local recurrence of breast cancer: conventionally fractionated partial external beam re-irradiation with curative intention. Strahlentherapie und Onkologie, 194(9), 806-814. https://dx.doi.org/10.1007/s00066-018-1315-1
MLA:
Janssen, S., et al. "Local recurrence of breast cancer: conventionally fractionated partial external beam re-irradiation with curative intention." Strahlentherapie und Onkologie 194.9 (2018): 806-814.
BibTeX: Download