Early CCR6 expression on B cells modulates germinal centre kinetics and efficient antibody responses

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Details zur Publikation

Autor(en): Reimer D, Lee AYS, Bannan J, Fromm P, Kara EE, Comerford I, Mccoll S, Wiede F, Mielenz D, Körner H
Zeitschrift: Immunology and Cell Biology
Jahr der Veröffentlichung: 2017
Band: 95
Heftnummer: 1
Seitenbereich: 33-41
ISSN: 0818-9641


Abstract

The CC-chemokine receptor 6 (CCR6) can be detected on naive and activated B cells. Counterintuitively, its absence accelerates the appearance of germinal centres (GCs) and increases the production of low-affinity antibodies. The detailed mechanism of CCR6 function during the humoral response has remained elusive, but previously we identified a distinct CCR6high B-cell population in vivo early after antigenic challenge. In this study, we defined this population specifically as early, activated pre-GC B cells. In accordance, we show that CCR6 is upregulated rapidly within hours on the protein or mRNA level after activation in vitro. In addition, only activated B cells migrated specifically towards CCL20, the specific ligand for CCR6. Lack of CCR6 increased the dark zone/light zone ratio of GC and led to decreased antigen-specific IgG1 and IgG2a antibody generation in a B-cell intrinsic manner in mixed bone marrow chimeras. In contrast, antigen-specific IgM responses were normal. Hence, CCR6 negatively regulates entry of activated, antigen-specific pre-GC B cells into the GC reaction.


FAU-Autoren / FAU-Herausgeber

Reimer, Dorothea
Molekular-Immunologische Abteilung in der Medizinischen Klinik 3


Autor(en) der externen Einrichtung(en)
Concord Repatriation General Hospital
Monash University
University of Adelaide
University of Tasmania (UTAS)


Zitierweisen

APA:
Reimer, D., Lee, A.Y.S., Bannan, J., Fromm, P., Kara, E.E., Comerford, I.,... Körner, H. (2017). Early CCR6 expression on B cells modulates germinal centre kinetics and efficient antibody responses. Immunology and Cell Biology, 95(1), 33-41. https://dx.doi.org/10.1038/icb.2016.68

MLA:
Reimer, Dorothea, et al. "Early CCR6 expression on B cells modulates germinal centre kinetics and efficient antibody responses." Immunology and Cell Biology 95.1 (2017): 33-41.

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Zuletzt aktualisiert 2019-27-03 um 04:08